| | 133613-71-5 Basic information More.. |
| Product Name: | galiellalactone | | Synonyms: | galiellalactone;SOIISBQQYAGDKM-QJSROADHSA-N;(4S,5aR,7aR,7bS)-5,5a,6,7,7a,7b-Hexahydro-7b-hydroxy-4-methylindeno[1,7-bc]furan-2(4H)-one;Indeno[1,7-bc]furan-2(4H)-one, 5,5a,6,7,7a,7b-hexahydro-7b-hydroxy-4-methyl-, (4S,5aR,7aR,7bS)- | | CAS: | 133613-71-5 | | MF: | C11H14O3 | | MW: | 194.23 | | EINECS: | | | Mol File: | 133613-71-5.mol |  |
Use
Galiellalactone was originally isolated from Galiella rufa as a plant growth regulator. Recently it was shown to inhibit IL-6 induced SEAP expression with IC50 values of 250-500 nM, blocking the binding of the activated Stat3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation of the Stat3 transcription factor.
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133613-71-5
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