| | 106516-24-9 Basic information More.. |
| Product Name: | SERTINDOLE | | Synonyms: | SERTINDOLE;SUBSTANCE 5364890;1-(2-{4-[5-CHLORO-1-(4-FLUORO-PHENYL)-1H-INDOL-3-YL]-PIPERIDIN-1-YL}-ETHYL)-IMIDAZOLIDIN-2-ONE;1-[2-[4-[5-Chloro-1-(4-fluorophenyl)-1h-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone;1-(4-Fluorophenyl)-5-chloro-3-[1-[2-[(tetrahydro-2-oxo-1H-imidazol)-1-yl]ethyl]piperidin-4-yl]-1H-indole;1-[2-[4-[1-(4-Fluorophenyl)-5-chloro-1H-indole-3-yl]piperidino]ethyl]imidazolidine-2-one;S-1991;LU-23-174 | | CAS: | 106516-24-9 | | MF: | C24H26ClFN4O | | MW: | 440.94 | | EINECS: | | | Mol File: | 106516-24-9.mol |  |
Use
Serdolect was launched in the UK for acute and chronic schizophrenia and
schizoaffective psychoses. It is synthetically available in three steps from 5chloro-l-
(4-fluorophenyl)-l H-indole. Sertindole is selective for the limbic areas of the brain
and has a high affinity for the serotinin 5-HT2 receptor where it behaves as an
antagonist. It has weak affinity for the α1-adrenergic receptor and no affinity for
dopamine D2 receptors. It is as effective as haloperidol but without the
extrapyramidal symptoms. This may be a consequence of the fact that it expresses
the c-fos protein in a manner different for haloperidol but similar to clozapine. It is
non-sedating, long lasting (several days after a single dose) and has an atypical
mode of action.
- SERTINDOLE USP/EP/BP
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- US $1.10 / g
- 2021-07-24
- CAS:106516-24-9
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons min
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106516-24-9
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