| | 26833-87-4 Basic information More.. |
| Product Name: | Homoharringtonine | | Synonyms: | HOMOHARRINGTONIN;HOMOHARRINGTONINE;HHT;cephalotaxine 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate;CEPHALOTAXINE, 4-METHYL-2-HYDROXY-2-[4-HYDROXY-4-METHYLPENTYL] BUTANEDIOATE ESTER;CEPHALOTAXINE 4-METHYL (2R)-2-HYDROXY-2-(4-HYDROXY-4-METHYLPENTYL)BUTANEDIOATE;4-methyl-cephalotaxin2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate(e;cephalotaxine,4-methyl(2r)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioa | | CAS: | 26833-87-4 | | MF: | C29H39NO9 | | MW: | 545.63 | | EINECS: | | | Mol File: | 26833-87-4.mol |  |
Use
The homoharringtonine is synthesized using -methyl--caprolactone (1) and ethanol as starting materials via ring opening and elimination of ethyl 5-methyl-4-hexenoate (2), 2 has condensation reaction with diethyl oxalate to give diethyl 2-(3-methyl-2-butenyl) malonate (3), 3 has -decarboxylation reaction with aqueous dimethylsulfoxide in the presence of sodium chloride to generate 6-methyl-2-oxo-5-heptenoic acid ethyl ester (4); 4 is subject to alkaline hydrolysis, oxalylation and further acylation of cephalotaxine to obtain 6-methyl-2-Oxo-5-heptenoic acid cephalomannine ester (6) and then subjected to a Rafalmacky reaction to give methyl 2-hydroxy-2-(4-methyl-3-pentenyl) succinate Cephalotaxine ester (7), 7 is subject to mercury hydroxylation and mercury removal reaction to obtain the end product, homoharringtonine. The reaction scheme is as follows:
Figure 2 is a chemical reaction route map for the laboratory synthesis of homoharringtonine.
- Homoharringtonine
-
- US $0.00 / Kg/Bag
- 2025-04-08
- CAS:26833-87-4
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 100kg
- Homoharringtonine
-
- US $0.00-0.00 / mg
- 2025-04-03
- CAS:26833-87-4
- Min. Order: 20mg
- Purity: 98% HPLC
- Supply Ability: 100kg
- Homoharringtonine
-
- US $0.00 / kg
- 2025-03-31
- CAS:26833-87-4
- Min. Order: 0.00100000kg
- Purity: 99%
- Supply Ability: 2kg
|
|
26833-87-4
Recommend Suppliers |
|