ATRACTYLOSIDE SODIUM SALT
| | 100938-11-2 Basic information More.. |
| Product Name: | ATRACTYLOSIDE SODIUM SALT | | Synonyms: | ATRACTYLOSIDE SODIUM;ATRACTYLOSIDE SODIUM SALT;ATRACTYLOSIDE;Atraotydin;ATRACTYLOSIDE SODIUM SALT FROM ATRACTYLIS GUMMIFERA;(2β,4α,15α)-15-Hydroxy-2-[[2-O-(3-Methyl-1-oxobutyl)-3,4-di-O-sulfo-β-D-glucopyranosyl]oxy]-19-norkaur-16-en-18-oic Acid DisodiuM Salt;Atractylic Acid DisodiuM Salt;Atractylin SodiuM Salt | | CAS: | 100938-11-2 | | MF: | C30H44Na2O16S2 | | MW: | 770.77 | | EINECS: | | | Mol File: | 100938-11-2.mol |  |
Use
A specific inhibitor of the adenine nucleotide translocase (ANT), which is a mitochondrial ADP/ATP carrier. It is also a proapoptotic ligand of ANT that induces pore formation by ANT, and results in p ermeabilization of the mitochondria membrane. Studies on rat hearts suggest that Atractyloside inhibits chloride channels from the mitochondrial membrane. It is used to probe the source of procaspase 8 in human fibroblasts and mouse clonal striatal cells, as related to death receptor-mediated apoptosis. ATRACTYLOSIDE SODIUM SALT induces the release of ahyaluronidase-induced murine WW domain-containing oxidore ductase from cultured COS-7 cells, with respect to tumor necrosis factor cytotoxicity.
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100938-11-2
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