57404-88-3 Basic information More..
Product Name:TRANS-7,8-DIHYDROXY-7,8-DIHYDRO-BENZO(A)PYRENE
Synonyms:TRANS-7,8-DIHYDROXY-7,8-DIHYDRO-BENZO(A)PYRENE;Benzo[a]pyrene-7,8-diol, 7,8-dihydro-, (7R,8R)-rel-;trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene (>90%);Benzo(a)pyrene, 7,8-dihydro-7,8-dihydroxy-, (E)-
CAS:57404-88-3
MF:C20H14O2
MW:286.32
EINECS:
Mol File:57404-88-3.mol
57404-88-3

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trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene is a metabolite of Benzopyrene (B205800). Benzo[a]pyrene (B205800), a prototypic PAH, is metabolized by cytochrome P 450 1A1/1B1. (-)-trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene (D452280) undergoes further P 4501A1/1B1-mediated metabolism to a carcinogen, which forms DNA-adducts primarily with 2'-deoxyguanosine. A carcinogen.

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