| | 937263-43-9 Basic information More.. |
| Product Name: | Tucatinib | | Synonyms: | ONT-380);N4-(4-([1;N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine;Irbinitinib;Irbinitinib(ARRY380);(R)-N6-(4-Methyl-4;5-dihydrooxazol-2-yl)-N4-(3-Methyl-4-(thiazol-2-ylMethoxy)phenyl)quinazoline-4;6-diaMine | | CAS: | 937263-43-9 | | MF: | C26H24N8O2 | | MW: | 480.52 | | EINECS: | 200-001-8 | | Mol File: | 937263-43-9.mol |  |
Use
Irbinitinib is also known as ARRY-380 or Tucatinib. ARRY-380 is an orally inhibitor of human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. It selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation. Therefore, ARRY-380 may be an alternative treatmentmethod for the treatment of HER2+ cancers.
- Tucatinib
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- US $0.00-0.00 / kg
- 2024-07-17
- CAS:937263-43-9
- Min. Order: 1kg
- Purity: ＞99.5% by HPLC
- Supply Ability: 100kg/month
- Tucatinib
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- US $0.00-0.00 / kg
- 2024-05-09
- CAS:937263-43-9
- Min. Order: 1kg
- Purity: 99%，single impurity＜0.1
- Supply Ability: 1 ton
- Irbinitinib
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- US $0.00 / KG
- 2023-06-19
- CAS:937263-43-9
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000KGS
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937263-43-9
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