| | 131359-24-5 Basic information More.. |
| Product Name: | (E,E)-Bis(2-hydroxybenzylidene)acetone
(2-HBA) | | Synonyms: | (E,E)-Bis(2-hydroxybenzylidene)acetone
(2-HBA);(1E,4E)-1,5-Bis(2-Hydroxyphenyl)-1,4-pentadien-3-one;HBB2;2-HBA;(E,E)-Bis(2-hydroxybenzylidene)acetone\n(2-HBA);2-HBA Exclusive;bis(2-hydroxybenzylidene)acetone;1,4-Pentadien-3-one, 1,5-bis(2-hydroxyphenyl)-, (1E,4E)- | | CAS: | 131359-24-5 | | MF: | C17H14O3 | | MW: | 266.29 | | EINECS: | | | Mol File: | 131359-24-5.mol |  |
Use
(E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) is a synthetic analogue of curcumin that displays strong NAD(P)H:quinone reductase (NQO1) inducer potency in Hepa 1c1c7 cells. 2-HBA, a double Michael reaction acceptor, can directly modify cysteine sulfhydryl groups in Keap1 and consequently suppress Nrf2 ubiquitination which in turn enhances the expression of antioxidative and cytoprotective enzymes. 2-HBA has also been shown to cause G2/M cell cycle arrest and p53-independent, caspase 3-mediated apoptosis.
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131359-24-5
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