| | 330600-85-6 Basic information More.. |
| Product Name: | Peramivir | | Synonyms: | (1S,2S,3R,4R)-3-((S)-1-AcetaMido-2-ethylbutyl)-4-guanidino-2-hydroxycyclopentanecarboxylic acid;(1S,2R,3R,4R)-3-(1-acetamido-2-ethyl-butyl)-4-(diaminomethylideneamino)-2-hydroxy-cyclopentane-1-carboxylic acid;(1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxycyclopentanecarboxylic acid;Aids114230;Aids-114230;Bcx-1812;Cyclopentanecarboxylic acid, 3-[(1S)-1-(acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxy-, (1S,2S,3R,4R)-;Rwj-270201 | | CAS: | 330600-85-6 | | MF: | C15H28N4O4 | | MW: | 328.41 | | EINECS: | | | Mol File: | 330600-85-6.mol |  |
Use
Peramivir is a neuraminidase (NA) inhibitor that was approved in Japan
in 2010 for treatment of patients with influenza. It is the only NA inhibitor
available for IV use and is the first of two NA inhibitors approved in 2010, the
second being the inhaled drug laninamivir octanoate .
Peramivir is the only NA inhibitor approved for IV use,which gives it a unique place in
influenza treatment for seriously ill patients. Peramivir was discovered
using structure-based drug design and is synthesized in six steps from
Boc-protected methyl (1S,4R)-4-amino-cyclopent-2-enecarboxylate, which
is prepared from 2-azabicyclo[2.2.1]hept-5-en-3-one. Cycloaddition
of the cyclopentene olefin with a nitrile oxide provided an intermediate
fused cyclopentane-dihydroisoxazole. Hydrogenolysis and acetylation set
up a fully functionalized cyclopentane with all four stereocenters established.
Deprotection of the amine and acid groups was followed by installation
of the guanidine moiety to provide peramivir. Like zanamivir and
oseltamivir, peramivir is a potent inhibitor of influenza virus A and B NA
[strain A(H1N1) IC50= 0.34 nM; strain A(H3N2) IC50= 0.60 nM; strain B
IC50= 1.36 nM]. However, peramivir is less potent against oseltamivirresistant
viruses that have the H275Y NA mutation. These viruses remain
sensitive to zanamivir. Peramivir is active against influenza A and B viruses
and has a lowenzymatic off-rate, suggesting that it could inhibitNAactivity
for a prolonged period and allow lower frequency of dosing. Peramivir has
proven efficacious in preclinical animal models of influenza infection.Peramivir is anew antiviral agent for influenza treatment; it can be used as neuraminidase inhibitor for treating human and avian influenza
Peramivir isamember of the class of guanidines that is used (as its trihydrate) for the treatment of acute uncomplicated influenza in patients 18 years and older who have been symptomatic for no more than two days.
- peramivir
-
- US $0.00 / kg
- 2024-03-28
- CAS:330600-85-6
- Min. Order: 25kg
- Purity: 98%
- Supply Ability: Inquiry
- Peramivir
-
- US $200.00 / kg
- 2023-06-26
- CAS:330600-85-6
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1000kg/Month
|
|
330600-85-6
Recommend Suppliers |
|