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Product Name:RADICICOL
Synonyms:(1AR,2Z,4E,14R,15AR)-8-CHLORO-1A,14,15,15A-TETRAHYDRO-9,11-DIHYDROXY-14-METHYL-6H-OXIRENO[E][2]BENZOXACYCLOTETRADECIN-6,12(7H)-DIONE;[1AS-(1AR*,2Z,4E,14*,15AR*)]-8-CHLORO-1A,14,15,15A-TETRAHYDRO-9,11-DIHYDROXY-14-METHYL-6H-OXIRENO[E][2]BENZOXACYCLOTETRADECIN-6,12(7H)-DIONE;5-CHLORO-6-(7,8-EPOXY-10-HYDROXY-2-OXO-3,5-UNDECADIENYL)-BETA-RESORCYLIC ACID MU-LACTONE;FO-4910;KF58332;KF9-A;MONORDEN;MONORODENE
CAS:12772-57-5
MF:C18H17ClO6
MW:364.78
EINECS:
Mol File:12772-57-5.mol
12772-57-5

Use

Radicicol is a resorcylic acid lactone, produced by several fungal species, that exhibits broad spectrum antifungal and antitumor activity. Radicicol has been the subject of extensive investigation and inhibits protein tyrosine kinase, induces the differentiation of HL-60 cells into macrophages, blocks cell cycle at G1 and G2, suppresses NIH 3T3 cell transformation by diverse oncogenes such as src, ras and mos, and also suppresses the expression of mitogen-inducible cyclooxygenase-2. As a cell differentiation modulator, radicicol has anti-angiogenic activity in vivo, inhibiting the proliferation of plasminogen activator production by vascular endothelial cells.

RADICICOL manufacturers

  • RADICICOL
  • US $1.00 / KG
  • 2020-01-19
  • CAS:12772-57-5
  • Min. Order: 1KG
  • Purity: 99.0%
  • Supply Ability: 100kg
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