| | 54526-94-2 Basic information More.. |
| Product Name: | STEFFIMYCIN B | | Synonyms: | STEFFIMYCIN B;1,6,11(2h)-naphthacenetrione,4-((6-deoxy-2,4-di-o-methyl-alpha-l-mannopyranosy;5,7-trihydroxy-3,9-dimethoxy-2-methyl-l)oxy)-4-dihydro-2;u40615;4-(2-O,4-O-Dimethyl-α-L-rhamnopyranosyloxy)-3,4-dihydro-2,5,7-trihydroxy-3,9-dimethoxy-2-methyl-1,6,11(2H)-naphthacenetrione;4-[(2-O,4-O-Dimethyl-6-deoxy-α-L-mannopyranosyl)oxy]-3,4-dihydro-2,5,7-trihydroxy-3,9-dimethoxy-2-methyl-1,6,11(2H)-naphthacenetrione;Steffimycin 4'-methyl ether;1,6,11(2H)-Naphthacenetrione, 4-((6-deoxy-2,4-di-o-methyl-alpha-L-mannopyranosyl)oxy)-3,4-dihydro-2,5,7-trihydroxy-3,9-dimethoxy-2-methyl- | | CAS: | 54526-94-2 | | MF: | C29H32O13 | | MW: | 588.56 | | EINECS: | | | Mol File: | 54526-94-2.mol |  |
Use
Steffimycin B is an anthracycline metabolite isolated from a Streptomyces sp., with antibacterial and antineoplastic properties. Crystallographic studies of binding to DNA suggest that it has a higher CpG base sequence specificity over the TpA step, similar to that of daunorubicin and nogalamycin. A close analogue was shown to be active against ras oncogene-expressed cells.
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54526-94-2
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