Use
Humans exposed briefly to vapors of 1-nitropropane were found to have concentrations
exceeding 100 p.p.m. irritating to the eyes (HSDB 1988). The chemical
may produce anorexia, nausea, vomiting, diarrhea as well as injury to the liver and
kidneys in exposed humans. High concentrations of the chemical also may
produce methemoglobinemia with cyanosis. 1-Nitropropane vapors also are
damaging to the lungs. 1-Nitropropane is, however, more acutely irritating to mucus membranes than 2-nitropropane. Despite this, the TLV for human exposure
to 2-nitropropane is less than that for 1-nitropropane, based on the carcinogenic
potential of 2-nitropropane in rats.