| | 129655-21-6 Basic information More.. |
| Product Name: | Bizelesin | | Synonyms: | 1,3-Bis[2-[[[(8S)-8β-chloromethyl-3,6,7,8-tetrahydro-4-hydroxy-1-methylbenzo[1,2-b:4,3-b']dipyrrol]-6-yl]carbonyl]-1H-indol-5-yl]urea;NSC-615291;U-77779;(8S,8'S)-6,6'-[Carbonylbis(iMino-1H-
indole-5,2-diylcarbonyl)]bis[8-(chloroMethyl)-3,6,7,8-tetrahydro-1-Methylbe;N,N'-Bis[2-[[(1S)-1-(chloroMethyl)-1,6-dihydro-5-hydroxy-8-Methylbenzo[1,2-b:4,3-b']dipyrrol-3(2H)-yl]carbonyl]-1H-indol-5-yl]urea;Bizelesin;1,3-bis[2-[(8S)-8-(chloromethyl)-4-hydroxy-1-methyl-7,8-dihydro-3H-pyrrolo[3,2-e]indole-6-carbonyl]-1H-indol-5-yl]urea;Urea, N,N'-bis[2-[[(1S)-1-(chloromethyl)-1,6-dihydro-5-hydroxy-8-methylbenzo[1,2-b:4,3-b']dipyrrol-3(2H)-yl]carbonyl]-1H-indol-5-yl]- | | CAS: | 129655-21-6 | | MF: | C43H36Cl2N8O5 | | MW: | 815.7 | | EINECS: | | | Mol File: | 129655-21-6.mol |  |
Use
As members of the cyclopropylpyrroloindole family, Adozelesin and Bizelesin cause genomic DNA lesions by alkylating DNA. Adozelesin induces single-strand DNA lesions, whereas Bizelesin induces both si
ngle-strand lesions and double-strand DNA cross-links.
liferation by different pathways (i.e., Adozelesin induced apoptosis, and Bizelesin induced senescence).
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129655-21-6
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Product Name:Bizelesin ;N,N'-Bis[2-[[(1S)-1-(chloroMethyl)-1,6-dihydro-5-hydroxy-8-Methylbenzo[1,2-b:4,3-b']dipyrrol-3(2H)-yl]carbonyl]-1H-indol-5-yl]urea; (8S,8'S)-6,6'-[Carbonylbis(iMino-1H-
indole-5,2-diylcarbonyl)]bis[8-(chloroMethyl)-3,6,7,8-tetrahydro-1-Methylbe
CAS:129655-21-6
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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60 |
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