| | 13010-47-4 Basic information More.. |
| Product Name: | Lomustine | | Synonyms: | (chloro-2-ethyl)-1-cyclohexyl-3-nitrosourea;(cloro-2-etil)-1-cicloesil-3-nitrosourea;1-(2-chloroethyl)-3-cyclohexyl-1-nitrosoure;1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-ure;belustine;nci-c04740;nsc79037;nsc-79037 | | CAS: | 13010-47-4 | | MF: | C9H16ClN3O2 | | MW: | 233.7 | | EINECS: | 235-859-2 | | Mol File: | 13010-47-4.mol |  |
Use
Lomustine is available in 10-, 40-, and 100-mg capsules fororal administration in the treatment of primary and metastaticbrain cancers and Hodgkin’s lymphoma. This lipophilicagent is well absorbed, widely distributed, and crosses theblood-brain barrier. Lomustine undergoes extensive hepaticmetabolism, which is mediated by CYP3A4 to give severalhydroxylated metabolites, which arise as a result of oxidationof the cyclohexyl ring. Several of these are more activethan the parent compound. Denitrosation and dechlorinationhave also been demonstrated to occur for lomustine as well.The intact drug was not found in plasma when the agent wasadministered orally. Elimination occurs primarily in theurine with an elimination half-life of 16 to 72 hours.Myelosuppression is dose limiting and presents in a mannersimilar to that seen with carmustine. Other toxicities includenausea, vomiting, anorexia, impotence, sterility, amenorrhea,and infertility. Pulmonary and renal toxicity are rarelyseen during standard-dose therapy but increase during highdosetherapy.
- Lomustine
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- US $0.00 / Kg/Bag
- 2024-12-27
- CAS:13010-47-4
- Min. Order: 1KG
- Purity: 98.5%~101.5%; USP42
- Supply Ability: 1000kg/month
- Lomustine
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- US $85.00-50.00 / mg
- 2024-11-19
- CAS:13010-47-4
- Min. Order:
- Purity: 99.86%
- Supply Ability: 10g
- Lomustine
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- US $2.70 / kg
- 2024-10-11
- CAS:13010-47-4
- Min. Order: 10kg
- Purity: 99.7%
- Supply Ability: 10000kg
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13010-47-4
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