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Product Name:APHS
Synonyms:APHS;2-(2-HEPTYNYLTHIO)-PHENOL ACETATE;PHENOL 2-(2-HEPTYNYLTHIO)-ACETATE;Aids081123;Aids-081123;o-(Acetophenyl)hept-2-ynyl sulphide;o-(Acetoxyphenyl)hept-2-ynyl sulphide;Phenol, 2-(2-heptyn-1-ylthio)-, 1-acetate
CAS:209125-28-0
MF:C15H18O2S
MW:262.37
EINECS:
Mol File:209125-28-0.mol
209125-28-0

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An O-acetyl, S-alkyl thio ether of 2-thio phenol. It is a potent inhibitor of both COX-1 and COX-2, with IC50 values of 17 and 0.8uM for human recombinant COX-1 and COX-2 respectively. APHS exhibits 20-fold selectivity toward the inhibition of COX-2, yet it is still more potent than aspirin in the inhibition of COX-1.

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