| | 950762-95-5 Basic information More.. |
| Product Name: | PCI 34051 | | Synonyms: | N-hydroxy-1-(4-Methoxybenzyl)-1H-indole-6-carboxaMide;PCI 34051;PCI-34051;1-(4-methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide;1H-Indole-6-carboxamide, N-hydroxy-1-[(4-methoxyphenyl)methyl]-;N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide;PCI-34051;PCI 34051;N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide | | CAS: | 950762-95-5 | | MF: | C17H16N2O3 | | MW: | 296.32 | | EINECS: | | | Mol File: | 950762-95-5.mol |  |
Use
PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias. PCI-34051 did not affect other hematopoietic or solid tumor lines. PCI-34051 treatment has been shown to significantly reduce cholesterol accumulation in Niemann-Pick type C1 gene mutated human fibroblast.
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950762-95-5
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