| | 116649-85-5 Basic information More.. |
| Product Name: | Ramatroban | | Synonyms: | BAY-U3405;3R-[[(4-FLUOROPHENYL)SULFONYL]AMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-PROPANOIC ACID;(3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propionic acid;3-[(3R)-3-(4-Fluorophenylsulfonylamino)-1,2,3,4-tetrahydro-9H-carbazole-9-yl]propionic acid;(R)-3-(3-(4-fluorophenylsulfonamido)-3,4-dihydro-1H-carbazol-9(2H)-yl)propanoic acid;RAFFINOSE UNDECAACETATE, D-(+)-(RG);(3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoicacid;RaMatroban(BAY-u3405) | | CAS: | 116649-85-5 | | MF: | C21H21FN2O4S | | MW: | 416.47 | | EINECS: | | | Mol File: | 116649-85-5.mol |  |
Use
Ramatroban, originally developed for the treatment of cardiovascular pathologies as
thromboembolism, was finally introduced in Japan for the treatment of allergic rhinitis. It is
a (3R)-enantiomer that can be synthesized in 5 steps from 3-oxo-1,2,3,4-
tetrahydrocarbazole by stereoselective reductive amination, using S-phenethylamine as
the chiral source, followed by hydrogenolysis, sulfonylation and finally 2-step Ncarboxyethylation.
Ramatroban is a potent antagonist of prostaglandin receptors (PGD2,
PGH2) and thromboxane receptors (TxA2); accordingly, it blocks the contractions induced
by thromboxane or TxA2-mimetics in animal and human airway smooth muscle. It also
prevents, when administered i.v., p.o. or by aerosol, bronchoconstriction induced by PGD2
or antigen. In animal models of nasal allergy, ramatroban inhibits antigen-induced
neutrophil infiltration into nasal mucosa and also inhibits nasal symptoms. In several
species including humans, it is well-absorbed, extensively protein-bound (>95%) and
eliminated mainly as a glucuro-conjugate; in man, its terminal half-life is 2 to 3 hours.
- Ramatroban
-
- US $300.00 / g
- 2021-11-02
- CAS:116649-85-5
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 100TONS
- Ramatroban
-
- US $15.00-10.00 / KG
- 2021-07-13
- CAS:116649-85-5
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- Ramatroban
-
- US $15.00-10.00 / KG
- 2021-07-09
- CAS:116649-85-5
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
|
|
116649-85-5
Recommend Suppliers |
|