Use
An antisense oligonucleotide, 21 bases in length, representing
the mirror image of a region of mRNA coding for a
regulatory protein of CMV. It is administered as the sodium
salt by intraocular injection. Experiments in monkeys suggest
that it has a very long elimination half-life (c. 3 days). Because
of its unique mode of action fomivirsen retains activity against
strains of CMV resistant to other antiviral agents.
Side effects commonly include ocular inflammation, which is
responsive to topical steroids, and raised intraocular pressure.