| 150812-12-7 Basic information More.. |
Product Name: | Retigabine | Synonyms: | Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]carbamate;RetigabineDiscontinued See: R189051;2-AMINO-4-(4-FLUORBENZYLAMINO)-1-ETHOXYCARBONYLAMINOBENZENE;D2312;N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic Acid Ethyl Ester;D 23129;Retigabin;Ezogabine impurity | CAS: | 150812-12-7 | MF: | C16H18FN3O2 | MW: | 303.33 | EINECS: | 629-886-2 | Mol File: | 150812-12-7.mol | ![150812-12-7](/CAS/GIF/150812-12-7.gif) |
Use
Retigabine was approved in March 2011 by the European Commission
for the adjunctive treatment of partial-onset seizures in adults who have
epilepsy; in June 2011, the U.S. FDA approved the same drug, known in
the United States as ezogabine.
Retigabine differs from all currently approved antiepileptic drugs in that it acts as a
selective positive allosteric modulator (opener) of KCNQ2-5 potassium
channels, which are key regulators of neuronal excitability. The
discovery of retigabine was based on modification of an analgesic agent
flupirtine that had serendipitously shown potent anticonvulsant activity in
animal models of epilepsy. Changing a central 2,3,6-triaminopyridine to a
1,2,4-triaminobenzene decreased analgesic activity while enhancing
antiepileptic activity. Retigabine (D-23129) was shown to be a broad
spectrum anticonvulsant with oral activity in a variety of animal models.
The mechanism of action of retigabine was discovered well after its
in vivo activity was recognized. Retigabine can be prepared by
reductive amination of 2-ethoxycarbonylamino-5-(4-fluorobenzylamino)-
nitrobenzene with 4-fluorobenzaldehyde, followed by hydrogenation in
the presence of Raney nickel.
- RETIGABINE
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- US $0.00-0.00 / KG
- 2024-07-15
- CAS:150812-12-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 5000
- Retigabine
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- US $145.00-445.00 / mg
- 2024-07-09
- CAS:150812-12-7
- Min. Order: 50mg
- Purity: 99%
- Supply Ability: 30
- Retigabine
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- US $5.00-0.10 / KG
- 2024-04-16
- CAS:150812-12-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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150812-12-7
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