| 61-25-6 Basic information More.. |
Product Name: | Papaverine hydrochloride | Synonyms: | Papaverine hydrochloride, 99% 5GR;papaverine hydrochloride:6,7-dimethoxy-1-(3,4-dimethoxybenzyl)-isoQUINOLINE hydrochloride: 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoQUINOLINE hydrochloride;Papaverine hydrochloride,99%;papaverin hydrochloride;papaverine hydrochloride 90.2%;Papaverine Hydrochloride (200 mg);Isoquinoline,1-[(3,4-diMethoxyphenyl)Methyl]-6,7-diMethoxy-, hydrochloride (1:1);1-[(3',4'-DIMETHOXYPHENYL)METHYL]-6,7-DIMETHOXYISOQUINOLINE HCL | CAS: | 61-25-6 | MF: | C20H22ClNO4 | MW: | 375.85 | EINECS: | 200-502-1 | Mol File: | 61-25-6.mol | |
Use
Papaverine hydrochloride,6,7-dimethoxy-1-veratrylisoquinoline hydrochloride,was isolated by Merck in 1848 from opium,in which it occurs to the extent of about 1%. Althoughits natural origin is closely related to morphine, the pharmacologicalactions of papaverine hydrochloride areunlike those of morphine. Its main effect is as a spasmolyticon smooth muscle, acting as a direct, nonspecificrelaxant on vascular, cardiac, and other smooth muscle.Because of its broad antispasmodic action on ACh muscarinicreceptors, it is often called a nonspecific antagonist.Papaverine hydrochloride has been used in the treatmentof peripheral vascular disorders, but its use is limitedby lack of potency. Papaverine hydrochloride interferes with the mechanismof muscle contraction by inhibiting the cyclic nucleotidephosphodiesterases in smooth muscle cells responsible forconverting cAMP and cyclic guanosine monophosphate(cGMP) to 5' -AMP and 5' -GMP, respectively. The increasedlevels of cAMP and cGMP are associated with muscle relaxation through their phosphorylation of myosinlight-chain kinase.PAPAVERINE HYDROCHLORIDE is Crystalline Solid
Papaverine hydrochloride,6,7-dimethoxy-1-veratrylisoquinoline hydrochloride,was isolated by Merck in 1848 from opium,in which it occurs to the extent of about 1%. Althoughits natural origin is closely related to morphine, the pharmacologicalactions of papaverine hydrochloride areunlike those of morphine. Its main effect is as a spasmolyticon smooth muscle, acting as a direct, nonspecificrelaxant on vascular, cardiac, and other smooth muscle.Because of its broad antispasmodic action on ACh muscarinicreceptors, it is often called a nonspecific antagonist.Papaverine hydrochloride has been used in the treatmentof peripheral vascular disorders, but its use is limitedby lack of potency. Papaverine hydrochloride interferes with the mechanismof muscle contraction by inhibiting the cyclic nucleotidephosphodiesterases in smooth muscle cells responsible forconverting cAMP and cyclic guanosine monophosphate(cGMP) to 5' -AMP and 5' -GMP, respectively. The increasedlevels of cAMP and cGMP are associated with muscle relaxation through their phosphorylation of myosinlight-chain kinase.
- Copavin
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- US $100.00 / bag
- 2022-03-25
- CAS:61-25-6
- Min. Order: 1bag
- Purity: 99
- Supply Ability: 500
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61-25-6
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