| | 114798-26-4 Basic information More.. |
| Product Name: | Losartan | | Synonyms: | 2-Butyl-4-chloro-5-(hydroxymethyl)-1-[(2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole;Compound 89;2-n-butyl-4-chloro-5-hydroxyMethyl-1-[(2'-(1H-tetrazole-5-yl)biph;2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)-biphenyl-4-yl]methyl]-1H-imidazol-5-methanol;(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol;dup89;nyl)-4-yl)methyl)-;2-butyl-4-chloro-1-[p-(o-1h-tetrazol-5-ylphenyl)benzyl]imidazole-5- methanol | | CAS: | 114798-26-4 | | MF: | C22H23ClN6O | | MW: | 422.91 | | EINECS: | 601-329-8 | | Mol File: | 114798-26-4.mol |  |
Use
Losartan, 2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5-yl-phenyl)benzyl]imidazole-5-methanol monopotassiumsalt (Cozarr), was the first nonpeptide imidazole to beintroduced as an orally active angiotensin II antagonist withhigh specificity for AT1. When administered to patients, itundergoes extensive first-pass metabolism, with the 5-methanol being oxidized to a carboxylic acid. This metabolismis mediated by CYP 2C9 and 3A4 isozymes. The 5-methanol metabolite is approximately 15 times more potentthan the parent hydroxyl compound. Because the parent hydroxylcompound has affinity for the AT1 receptor, strictlyspeaking, it is not a prodrug.
- Losartan
-
- US $0.00-0.00 / Kg/Bag
- 2024-09-10
- CAS:114798-26-4
- Min. Order: 1Kg/Bag
- Purity: 99% up, High Density
- Supply Ability: 20 tons
- Losartan
-
- US $238.00 / Kg/Bag
- 2024-08-30
- CAS:114798-26-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1T
- Losartan
-
- US $5.00 / kg
- 2024-04-24
- CAS:114798-26-4
- Min. Order: 1kg
- Purity: 99.92%
- Supply Ability: 50000tons
|
|
114798-26-4
Recommend Suppliers |
|