2,3-Dimercaptopropane-1-Sulfonic Acid

Use

After 14C-2,3-dimercaptopropane-1-sulfonic acid (DMPS) is administered orally to rabbits, disulfide metabolites of DMPS are identified in the urine, which are cyclic polymeric disulfides of dimeric and trimeric forms and acyclic polymeric disulfides of DMPS. One of the acyclic disulfides is a DMPS dimer. The cyclic disulfides increase with time, suggesting that the acyclic forms are intermediates and oxidized to the cyclic forms. The rapid formation of stable 8- membered cyclic dimeric and 12-membered cyclic trimeric disulfides of DMPS strongly suggests that oxidation ? reductions are occurring. Both spontaneous and enzymatic oxidation mechanisms appear to be involved.