| | 330784-47-9 Basic information More.. |
| Product Name: | Avanafil | | Synonyms: | 4-[[(3-Chloro-4-Methoxyphenyl)Methyl]
aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide;Avanafil 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide;avanfil;(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-yl;avanafil:4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)-1-pyrrolidinyl)-n-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide: (s)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylami;(S)-4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2pyrimidinylmethyl)-5-pyrimidinecarboxamide;(S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine;4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide | | CAS: | 330784-47-9 | | MF: | C23H26ClN7O3 | | MW: | 483.95 | | EINECS: | 000-000-0 | | Mol File: | 330784-47-9.mol |  |
Use
Avanafil (Zepeed) was approved by the Korean Health Ministry for the
treatment of erectile dysfunction (ED) in August 2011. Avanafil is a
highly selective type 5 phosphodiesterase (PDE5) inhibitor.
Avanafil is reported to be the most selective PDE5
inhibitor on the market. The onset of Tmax and half-life also varies among
the marketed PDE5 inhibitors. Sildenafil has a Tmax at 1 h and a half-life of
3–5 h. Vardenafil is somewhat similar with a Tmax of 0.6 h and a half-life of
4–6 h. Tadalafil has the longest half-life among the marketed drugs with a
half-life of 17 h. Avanafil has a fast onset of action reaching Tmax in 0.6 h
with a half-life of 1.2 h. A synthesis of avanafil (TA-1790) is described
in the patent literature. The main elimination route of avanafil
is through the bile and feces. Avanafil was also found to be reabsorbed
through enterohepatic recirculation.
- Avanafil
-
- US $200.00 / g
- 2024-08-24
- CAS:330784-47-9
- Min. Order: 1g
- Purity: 99.99%
- Supply Ability: 1000kg
- Avanafil
-
- US $10.00-10.00 / ASSAYS
- 2024-08-24
- CAS:330784-47-9
- Min. Order: 1ASSAYS
- Purity: 99%
- Supply Ability: 100kg
- Avanafil
-
- US $30.00 / Box
- 2024-08-24
- CAS:330784-47-9
- Min. Order: 1Box
- Purity: 99.99%
- Supply Ability: 10000000000
|
|
330784-47-9
Recommend Suppliers |
|