1,4-O-DidesMethyl rac-Niranthin
| | 81263-83-4 Basic information More.. |
| Product Name: | 1,4-O-DidesMethyl rac-Niranthin | | Synonyms: | 1,4-O-DidesMethyl rac-Niranthin;WTRAXKOXNKPSLF-IRXDYDNUSA-N;1,4-Butanediol, 2-[(3,4-dimethoxyphenyl)methyl]-3-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]-, (2R,3R)-rel- | | CAS: | 81263-83-4 | | MF: | C22H28O7 | | MW: | 404.45 | | EINECS: | | | Mol File: | 81263-83-4.mol |  |
Use
1,4-O-Didesmethyl rac-Niranthin is an intermediate in the synthesis of rac-Niranthin (N481000), a lignan compound isolated from the plant Phyllanthus amarus and shows anti-leishmanial activity. It acts through induction of topoisomerase I-mediated DNA-protein adduct formation in Leishmania cells triggering apoptosis of cellular nucleases. It also maintains the ability to reduce uric acid concentrations through xanthine oxidase inhibition.
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81263-83-4
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