| | 134308-13-7 Basic information More.. |
| Product Name: | Tolcapone | | Synonyms: | TOLOCAPONE;3,4-DIHYDROXYL-5-NITROBENZENYL,4-METHYLBENZENYL KETONE, TALCAPONE;Tolcapone (200 mg);Methanone, (3,4-dihydroxy-5-nitrophenyl)(4-Methylphenyl)-;(3,4-Dihydroxy-5-nitrophenyl)(p-tolyl)methanone;3,4-DIHYDROXYL-5-NITROBENZYL,4'-METHYLBENZENYL KETONE;(3,4-Dihydroxy-5-nitrophenyl);TALCAPONE | | CAS: | 134308-13-7 | | MF: | C14H11NO5 | | MW: | 273.24 | | EINECS: | | | Mol File: | 134308-13-7.mol |  |
Use
Tolcapone, 3,4-dihydroxy-4'-methyl-5-nitrobenzophenone (Tasmar), is a yellow, odorless, nonhygroscopic,crystalline compound (pKa＝4.78). Tolcapone israpidly absorbed after oral administration. Tolcapone ishighly bound to plasma albumin (＞98%), and its distributionis therefore restricted. Tolcapone has low first-pass metabolism.It is almost completely metabolized in the liver before excretion, and 60% is excreted by the kidney. The majormetabolite of tolcapone is an inactive glucuronide conjugate.COMT inhibitors increase chronotropic and arrhythmogeniceffects of epinephrine.Tolcapone is indicated as an adjunctto levodopa/carbidopa for the management of signs andsymptoms of PD.
- Tolcapone
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- US $1.00 / KG
- 2019-07-06
- CAS: 134308-13-7
- Min. Order: 1G
- Purity: 98%
- Supply Ability: 100KG
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134308-13-7
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