| | 62645-28-7 Basic information More.. |
| Product Name: | RO 106-9920 | | Synonyms: | RO 106-9920;TETRAZOLOPYRIDAZINE-PHENYLSULFOXIDE;6-(PHENYLSULFINYL)TETRAZOLO[1,5-B]PYRIDAZINE;Tetrazolo[1,5-b]pyridazine, 6-(phenylsulfinyl)-;Ro 106-9920
DISCONTINUED;Ro 106 9920,Ro 1069920 | | CAS: | 62645-28-7 | | MF: | C10H7N5OS | | MW: | 245.26 | | EINECS: | | | Mol File: | 62645-28-7.mol |  |
Use
Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Ro 106-9920 blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.
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62645-28-7
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