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Fatty Acid Binding Protein 3

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Fatty Acid Binding Protein 3 Basic information
Product Name:Fatty Acid Binding Protein 3
Synonyms:ALBP;A-FABP;ADIPOCYTE-FABP;LIVER-FABP;FABP1 (HUMAN RECOMBINANT);FABP2 (HUMAN RECOMBINANT);FABP3 (HUMAN RECOMBINANT);FABP4 (HUMAN RECOMBINANT)
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MW:0
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Mol File:Mol File
Fatty Acid Binding Protein 3 Structure
Fatty Acid Binding Protein 3 Chemical Properties
storage temp. −20°C
Safety Information
Hazard Codes B
WGK Germany 3
MSDS Information
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SigmaAldrich English
Fatty Acid Binding Protein 3 Usage And Synthesis
DescriptionFatty acid binding protein 1 (FABP1) is one of nine known cytosolic fatty acid binding proteins ranging in size from 14-15 kDa containing 127-132 amino acids. Members of this protein family exhibit high affinity for small lipophilic ligands and were named according to the tissue from which they were initially isolated. Studies suggest that FABPs are involved in the uptake and metabolism of fatty acids, in the maintenance of cellular membrane fatty acid levels, in intracellular trafficking of these substrates, in the modulation of specific enzymes of lipid metabolic pathways, and in the modulation of cell growth and differentiation. FABP family members have highly conserved three dimensional structures and 22-73% amino acid sequence similarity. FABP1 is composed of ten antiparallel β strands that form a barrel and have a bigger binding pocket than the other FABPs allowing it to accommodate two fatty acids into its binding pocket. Expression of FABP1 is decreased in hepatoblastoma and hepatocellular carcinoma making the protein a potential tumor marker. Moreover, studies have suggested FABP1 as a potential biomarker for both liver and kidney injury.
Fatty Acid Binding Protein 3 Preparation Products And Raw materials
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