吡啶-3-乙炔
| 中文名称 | 吡啶-3-乙炔 |
|---|---|
| 中文同义词 | 吡啶-3-乙炔;3-(1H-1,2,3-三唑-5-基)吡啶;3-(1H-1,2,3-三唑-4-基)吡啶;化合物3-TYP;3-(1H-1,2,3-噻唑-4-基)吡啶;3-(1H-1,2,3-三唑-4-)砒啶 |
| 英文名称 | Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI) |
| 英文同义词 | Pyridine, 3-(1H-1,2,3-triazol-4-yl)- (9CI);3-(1H-1,2,3-triazol-4-yl)pyridine;3-TYP;Pyridine(3-TYP);3-TYP;3 TYP;3TYP;CS-2754;3-(1H-1;2;3-TRIAZOL-4-YL) PYRIDINE;3 TYP;3TYP;3-triazol-4-yl) pyridine |
| CAS号 | 120241-79-4 |
| 分子式 | C7H6N4 |
| 分子量 | 146.15 |
| EINECS号 | |
| 相关类别 | API;PYRIDINE |
| Mol文件 | 120241-79-4.mol |
| 结构式 |  |
吡啶-3-乙炔 性质
| 熔点 | 180-182 °C(Solv: ethyl acetate (141-78-6); ethyl ether (60-29-7)) |
|---|---|
| 沸点 | 386.6±17.0 °C(Predicted) |
| 密度 | 1.296±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMF：10mg/mL； DMF:PBS (pH 7.2) (1:5)：0.16 mg/mL； DMSO：10mg/mL；乙醇：5mg/mL |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 7.54±0.70(Predicted) |
| 颜色 | 白色至米白色 |
| Target | Value |
|
SIRT3
(cell-free) | 16 nM |
|
SIRT1
(cell-free) | 88 nM |
|
SIRT2
(cell-free) | 92 nM |
在暴露于镉的HepG2细胞中，3-TYP可减弱由褪黑色素诱导的去乙酰化SOD2表达增加及抑制SOD2活性。
3-TYP (50 mg/kg, i.p.) does not significantly influence the LVEF, LVFS, infarct size, serum LDH levels, apoptosis, and oxidative stress compared with those of the Sham group. Moreover, 3-TYP has little effect on gp91phox, Nrf2, NQO 1, Bax, Bcl-2, Caspase-3, and cleaved Caspase-3 expression levels, compared with the Sham group. 3-TYP significantly decreases SIRT3 activity and increases the acetylation of SOD2 compared with that in the control group, without influencing SIRT3 expression. 3-TYP attenuates the cardioprotective effects of melatonin by decreasing the LVEF and LVFS after 24 hour of reperfusion. 3-TYP also increases the infarct size, serum LDH levels, and apoptotic ratio compared with those in the IR+Mel group.
安全信息
| 海关编码 | 2933998090 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-108331 | 吡啶-3-乙炔 3-TYP | 120241-79-4 | 5mg | 600元 |
| 2024/04/30 | HY-108331 | 吡啶-3-乙炔 3-TYP | 120241-79-4 | 10mM * 1mLin DMSO | 660元 |