| Company Name: |
Shanghai Chaolan Chemical Technology Center
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QQ:65489617 15618227136 |
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info@SuperLan-chem.com |
| Products Intro: |
Product Name:KIF18A-IN-3
CAS:2600577-49-7
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Email: |
sales@dcchemicals.com |
| Products Intro: |
Product Name:KIF18A-IN-3
CAS:2600577-49-7
Purity:98% HPLC Package:100mg，250mg，1g
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| | Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[[(1-methylcyclopropyl)sulfonyl]amino]- Basic information |
| | Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[[(1-methylcyclopropyl)sulfonyl]amino]- Chemical Properties |
| density | 1.37±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | form | Solid | | pka | 8.51±0.20(Predicted) | | color | White to off-white |
| | Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[[(1-methylcyclopropyl)sulfonyl]amino]- Usage And Synthesis |
| Biological Activity | KIF18A-IN-3 is a potent KIF18A inhibitor (IC50=61 nM). KIF18A-IN-3 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-3 can be used for researching cancer[1].
KIF18A-IN-3 (compound 24) exhibits a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours[1].Pharmacokinetic Parameters of KIF18A-IN-3 in female CD-1 mice[1]. IP (100 mg/kg) Cmax (μM)26.5AUC0-24 (μM.h)269 C24h (μM)0.8PPB (fu)0.015 | | References | [1]. Tamayo NA, et al. Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe. J Med Chem. 2022;65(6):4972-4990. |
| | Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[[(1-methylcyclopropyl)sulfonyl]amino]- Preparation Products And Raw materials |
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