Company Name: |
TargetMol Chemicals Inc.
|
Tel: |
15002134094 |
Email: |
marketing@targetmol.cn |
Products Intro: |
Product Name:BRD7539 CAS:2057420-00-3 Purity:0 Package:100mg/RMB 31500;50mg/RMB 24300;25mg/RMB 18300
|
|
| BRD-7539 Basic information |
Product Name: | BRD-7539 | Synonyms: | BRD 7539;BRD7539;BRD-7539;1-Azetidinecarboxamide, 2-cyano-3-[4-[2-(3-fluorophenyl)ethynyl]phenyl]-4-(hydroxymethyl)-N-propyl-, (2S,3S,4S)- | CAS: | 2057420-00-3 | MF: | C23H22FN3O2 | MW: | 391.44 | EINECS: | | Product Categories: | | Mol File: | 2057420-00-3.mol | |
| BRD-7539 Chemical Properties |
Boiling point | 643.3±55.0 °C(Predicted) | density | 1.29±0.1 g/cm3(Predicted) | pka | 13.89±0.70(Predicted) |
| BRD-7539 Usage And Synthesis |
Description | BRD7539B is a Dihydroorotate dehydrogenase (DHODH) inhibitor . RD7539 had shown to target PfDHODH (IC50 = 0.033 μM) selectively over human (Hs) DHODH (IC50 > 50 μM). BRD7539 was reported to have potent activity against both multidrug-resistant asexual blood-stage (P. falciparum, Dd2_x000D_
strain, EC50 = 0.010 μM) and liver-stage (P. berghei, EC50 =0.015 μM) parasites but no activity against sexual blood-stage (P. falciparum, stages IV?V, EC50 > 20 μM) parasites. BRD7539 is an azetidine carbonitrile with three contiguous stereocenters (2S,3S,4S), and stereochemistry-based structure?_x000D_
activity relationships (SSARs) showed that only two of eight possible stereoisomers are active. |
| BRD-7539 Preparation Products And Raw materials |
|