妥洛帕泛
中文名称 | 妥洛帕泛 |
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中文同义词 | 妥洛帕泛;化合物 T17178 |
英文名称 | Tulopafant |
英文同义词 | Tulopafant;1H,3H-Pyrrolo[1,2-c]thiazole-7-carboxamide, N-(3-benzoylphenyl)-3-(3-pyridinyl)-, (+)- |
CAS号 | 116289-53-3 |
分子式 | C25H19N3O2S |
分子量 | 425.51 |
EINECS号 | |
相关类别 | |
Mol文件 | 116289-53-3.mol |
结构式 |
妥洛帕泛 性质
沸点 | 613.3±55.0 °C(Predicted) |
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密度 | 1.32±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 13.51±0.70(Predicted) |
Preincubation of neutrophils with Tulopafant (RP 59227) results in a concentration-dependent decrease in chemiluminescence produced by PAF primed cells.
Tulopafant (RP 59227) effectively reduces myocardial infarct size and reduces the incidence of ischemia and reperfusion-induced arrhythmias in barbital-anesthetized dogs.Histological examination reveals marked diminution of both interstitial hemorrhage and deposition of platelet and granulocytes in capillaries of cardiac xenografts when recipient animals are pretreated with Tulopafant.