| Company Name: |
GIHI CHEMICALS CO.,LIMITED |
| Tel: |
+8618058761490 |
| Email: |
info@gihichemicals.com |
| Products Intro: |
Product Name:4,19-Dioxabicyclo[13.3.1]nonadec-12-en-3-one,1,17-dihydroxy-10,11,18-trimethoxy-2,14,16-trimethyl-5-phenyl-,(1R,2S,5S,10S,11R,12E,14S,15S,16S,17S,18R)-
CAS:122547-72-2
Purity:99 Package:5KG;1KG,25kg
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| Company Name: |
Chizhou Kailong Import and Export Trade Co., Ltd.
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| Tel: |
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| Email: |
xg01_gj@163.com |
| Products Intro: |
Product Name:4,19-Dioxabicyclo[13.3.1]nonadec-12-en-3-one,1,17-dihydroxy-10,11,18-triMethoxy-2,14,16-triMethyl-5-phenyl-,(1R,2S,5S,10S,11R,12E,14S,15S,16S,17S,18R)-
CAS:122547-72-2
Purity:98%Min
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| | Soraphen A Basic information |
| Product Name: | Soraphen A | | Synonyms: | Soraphen A;C11300;4,19-Dioxabicyclo[13.3.1]nonadec-12-en-3-one,1,17-dihydroxy-10,11,18-triMethoxy-2,14,16-triMethyl-5-phenyl-,(1R,2S,5S,10S,11R,12E,14S,15S,16S,17S,18R)-;(1S,2S,3Z,5R,6S,11S,14S,15R,16R,17S,18S)-15,17-dihydroxy-5,6,16-trimethoxy-2,14,18-trimethyl-11-phenyl-12,19-dioxabicyclo[13.3.1]nonadec-3-en-13-one | | CAS: | 122547-72-2 | | MF: | C29H44O8 | | MW: | 520.65 | | EINECS: | | | Product Categories: | | | Mol File: | 122547-72-2.mol |  |
| | Soraphen A Chemical Properties |
| | Soraphen A Usage And Synthesis |
| Description | Soraphen A was originally isolated from the culture broth of Sorangium cellulosum, a soil-dwelling myxobacterium, for its potent antifungal activity (Gerth et al. 1994, Gerth et al. 2003). This polyketide natural product contains an unsaturated 18-membered lactone ring, an extracyclic phenyl ring, 2 hydroxyl groups, 3 methyl groups, and 3 methoxy groups (Bedorf et al. 1993, Ligon et al. 2002) . There is also a 6-membered ring within the macrocycle formed by a hemiketal between the C3 carbonyl and C7 hydroxyl. | | Uses | Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. It has demonstrated strong promise as a broad-spectrum fungicide against various plant pathogenic fungi (Pridzun et al. 1995). | | Definition | ChEBI: Soraphen A is a macrolide and an agent highly effective against plant-pathogenic fungi. It was extensively researched for agricultural use until it was discovered to be a teratogen. It has a role as a bacterial metabolite, an EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor and a teratogenic agent. It is a macrolide, an ether, a cyclic hemiketal and an olefinic compound. | | References | Total Synthesis of the Acetyl CoA Carboxylase Inhibitor Soraphen A: Asymmetric Tsuji Reduction Enables Successive Olefin Metathesis. DOI:10.1021/jacs.1c12063
Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. DOI:10.1016/j.bcp.2010.12.014
https://www.cell.com/fulltext/S1097-2765(04)00725-7 |
| | Soraphen A Preparation Products And Raw materials |
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