Company Name: |
Cayman Chemical Company
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Tel: |
(800) 364-9897 |
Email: |
cayman@caymanchem.com |
Products Intro: |
Product Name:TG11-77 (hydrochloride) CAS:2550393-38-7
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| 5-Pyrimidinecarboxamide, 2-[(4,6-dimethyl-2-pyridinyl)amino]-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-, hydrochloride (1:1) Basic information |
| 5-Pyrimidinecarboxamide, 2-[(4,6-dimethyl-2-pyridinyl)amino]-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-, hydrochloride (1:1) Chemical Properties |
solubility | DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml | form | A crystalline solid |
| 5-Pyrimidinecarboxamide, 2-[(4,6-dimethyl-2-pyridinyl)amino]-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-, hydrochloride (1:1) Usage And Synthesis |
Description | TG11-77 is a brain-permeable antagonist of the prostaglandin E2 (PGE2) receptor subtype EP2 (KB = 9.7 nM).1 It is selective for EP2 over DP1, EP4, and IP receptors (KBs = 7,320, 5,300, and >10,000 nM, respectively). TG11-77 (0.3 and 1 μM) inhibits the expression of genes encoding COX-2, IL-1β, and IL-6 induced by LPS and the EP2 receptor agonist ONO-AE1-259-01 in mouse BV-2 microglia expressing human EP2 receptors. | References | 1. Amaradhi, R., Banik, A., Mohammed, S., et al. Potent, selective, water soluble, brain-permeable EP2 receptor antagonist for use in central nervous system disease models J. Med. Chem. 63(3),1032-1050(2020). |
| 5-Pyrimidinecarboxamide, 2-[(4,6-dimethyl-2-pyridinyl)amino]-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-, hydrochloride (1:1) Preparation Products And Raw materials |
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