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5-Pyrimidinecarboxamide, 2-[(4,6-dimethyl-2-pyridinyl)amino]-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-, hydrochloride (1:1)

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5-Pyrimidinecarboxamide, 2-[(4,6-dimethyl-2-pyridinyl)amino]-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-, hydrochloride (1:1) Suppliers list
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Products Intro: Product Name:TG11-77 hydrochloride
CAS:2550393-38-7
Purity:98% Package:1mg;5mg;10mg
Company Name: Cayman Chemical Company  
Tel: (800) 364-9897
Email: cayman@caymanchem.com
Products Intro: Product Name:TG11-77 (hydrochloride)
CAS:2550393-38-7
5-Pyrimidinecarboxamide, 2-[(4,6-dimethyl-2-pyridinyl)amino]-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-, hydrochloride (1:1) Basic information
Product Name:5-Pyrimidinecarboxamide, 2-[(4,6-dimethyl-2-pyridinyl)amino]-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-, hydrochloride (1:1)
Synonyms:5-Pyrimidinecarboxamide, 2-[(4,6-dimethyl-2-pyridinyl)amino]-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-, hydrochloride (1:1);2-((4,6-dimethylpyridin-2-yl)amino)-N-(2-(2-methyl-1H-indol-3-yl)ethyl)pyrimidine-5-carboxamide, monohydrochloride
CAS:2550393-38-7
MF:C23H25ClN6O
MW:436.94
EINECS:
Product Categories:
Mol File:2550393-38-7.mol
5-Pyrimidinecarboxamide, 2-[(4,6-dimethyl-2-pyridinyl)amino]-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-, hydrochloride (1:1) Structure
5-Pyrimidinecarboxamide, 2-[(4,6-dimethyl-2-pyridinyl)amino]-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-, hydrochloride (1:1) Chemical Properties
solubility DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
form A crystalline solid
Safety Information
MSDS Information
5-Pyrimidinecarboxamide, 2-[(4,6-dimethyl-2-pyridinyl)amino]-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-, hydrochloride (1:1) Usage And Synthesis
DescriptionTG11-77 is a brain-permeable antagonist of the prostaglandin E2 (PGE2) receptor subtype EP2 (KB = 9.7 nM).1 It is selective for EP2 over DP1, EP4, and IP receptors (KBs = 7,320, 5,300, and >10,000 nM, respectively). TG11-77 (0.3 and 1 μM) inhibits the expression of genes encoding COX-2, IL-1β, and IL-6 induced by LPS and the EP2 receptor agonist ONO-AE1-259-01 in mouse BV-2 microglia expressing human EP2 receptors.
References1. Amaradhi, R., Banik, A., Mohammed, S., et al. Potent, selective, water soluble, brain-permeable EP2 receptor antagonist for use in central nervous system disease models J. Med. Chem. 63(3),1032-1050(2020).
5-Pyrimidinecarboxamide, 2-[(4,6-dimethyl-2-pyridinyl)amino]-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-, hydrochloride (1:1) Preparation Products And Raw materials
Tag:5-Pyrimidinecarboxamide, 2-[(4,6-dimethyl-2-pyridinyl)amino]-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-, hydrochloride (1:1)(2550393-38-7) Related Product Information