| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Ph-HTBA
CAS:2368927-41-5
Purity:0 Package:50mg/RMB 13800;25mg/RMB 10600;100mg/RMB 17500
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| | Acetic acid, 2-(5,7,8,9-tetrahydro-5-hydroxy-2-phenyl-6H-benzocyclohepten-6-ylidene)-, (2E)- Basic information |
| Product Name: | Acetic acid, 2-(5,7,8,9-tetrahydro-5-hydroxy-2-phenyl-6H-benzocyclohepten-6-ylidene)-, (2E)- | | Synonyms: | Acetic acid, 2-(5,7,8,9-tetrahydro-5-hydroxy-2-phenyl-6H-benzocyclohepten-6-ylidene)-, (2E)-;Ph-HTBA | | CAS: | 2368927-41-5 | | MF: | C19H18O3 | | MW: | 294.34 | | EINECS: | | | Product Categories: | | | Mol File: | 2368927-41-5.mol |  |
| | Acetic acid, 2-(5,7,8,9-tetrahydro-5-hydroxy-2-phenyl-6H-benzocyclohepten-6-ylidene)-, (2E)- Chemical Properties |
| Boiling point | 557.6±50.0 °C(Predicted) | | density | 1.290±0.06 g/cm3(Predicted) | | pka | 3.94±0.41(Predicted) |
| | Acetic acid, 2-(5,7,8,9-tetrahydro-5-hydroxy-2-phenyl-6H-benzocyclohepten-6-ylidene)-, (2E)- Usage And Synthesis |
| Description | Ph-HTBA a Novel High-Affinity Brain-Penetrant Stabilizer of the CaMKIIα Hub Domain. Ph-HTBA showed enhanced mid-nanomolar affinity for the CaMKIIα binding site and a marked hub thermalstabilization effect along with a distinct CaMKIIα Trp403 flip upon binding. Moreover, Ph-HTBA has good cellular permeability and low microsomal clearance and shows brain permeability after systemic administration to mice, signified by a high Kp, uu value (0.85). Ph-HTBA is a promising candidate for CaMKIIα-associated pharmacological interventions and future clinical development. |
| | Acetic acid, 2-(5,7,8,9-tetrahydro-5-hydroxy-2-phenyl-6H-benzocyclohepten-6-ylidene)-, (2E)- Preparation Products And Raw materials |
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