Amtolmetin guacil

Amtolmetin guacil Suppliers list
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Email: sales@alchempharmtech.com
Products Intro: Product Name:2-Methoxyphenyl 2-(2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)acetamido)acetate
CAS:87344-06-7
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-48279
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:amtolmetin guacil
CAS:87344-06-7
Purity:0.99 Package:1kg
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: factory@coreychem.com
Products Intro: Product Name: Amtolmetin guacil
CAS:87344-06-7
Purity:85.0-99.8% Package:1KG;1USD
Company Name: SIMAGCHEM CORP
Tel: +86-13806087780
Email: sale@simagchem.com
Products Intro: Product Name:Amtolmetin Guacil
CAS:87344-06-7
Purity:0.99 Package:1kg,5kg,25kgs,200kgs;bulk
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Amtolmetin guacil;MED 15;ST679;ST-679;ST 679;MED-15;MED15
CAS:87344-06-7
Package:5 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

Amtolmetin guacil manufacturers

  • Amtolmetin guacil
  • Amtolmetin guacil pictures
  • $15.00 / 1KG
  • 2021-08-11
  • CAS:87344-06-7
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Amtolmetin guacil
  • 		Amtolmetin guacil pictures
  • $1.00 / 1KG
  • 2019-12-25
  • CAS:87344-06-7
  • Min. Order: 1KG
  • Purity: 85.0-99.8%
  • Supply Ability: 20 tons
Amtolmetin guacil Basic information
Product Name:Amtolmetin guacil
Synonyms:2-(2-Methoxyphenyl)-2-(N-{1-Methyl-5-[(4-Methylphenyl)carbonyl]-1H-pyrrol-2-yl}acetaMido)acetate;ArtroMed;Eufans;AMtolMethin Guacil;AMtolMetin Guacyl;N-[2-[1-Methyl-5-(4-Methylbenzoyl)-1H-pyrrol-2-yl]acetyl]glycine 2-Methoxyphenyl Ester;2-Methoxyphenyl 2-(2-(1-Methyl-5-(4-Methylbenzoyl)-1H-pyrrol-2-yl)acetaMido)acetate;2-methoxyphenyl1-methyl-5-p-methylbenzoylpyrrole-2-acetoamidoacetate
CAS:87344-06-7
MF:C24H24N2O5
MW:420.46
EINECS:
Product Categories:Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:87344-06-7.mol
Amtolmetin guacil Structure
Amtolmetin guacil Chemical Properties
Melting point 117-120°
Boiling point 663.3±55.0 °C(Predicted)
density 1.19±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka13.90±0.46(Predicted)
color Pale Brown to Light Brown
CAS DataBase Reference87344-06-7(CAS DataBase Reference)
Safety Information
ToxicityLD50 in male mice, rats (mg/kg): 1370, 1100 i.p.; >1500, 1450 orally (Baglioni)
MSDS Information
Amtolmetin guacil Usage And Synthesis
DescriptionAmtolmetin guacil is an orally active non-steroidal antiinflammatory drug (NSAID) introduced for the treatment of osteoarthritis, rheumatoid arthritis and post-operative pain. Amtolmetin guacil is reported to elicit a more rapid and improved analgesic action than other agents such as paracetamol. In models of adjuvant arthritis and rheumatic diseases, amtolmetin guacil is more efficacious than existing drugs such as naproxen, indomethacin and piroxicam. As a non-acidic prodrug of tolmetin, it has similar in vivo activity to the parent but with minor ulcerogenic action, lower acute toxicity, and excellent biological and gastric tolerability.
OriginatorSigma Tau (Italy)
UsesAnalgesic; anti-inflammatory used in the treatment of rheumatoid arthritis,
DefinitionChEBI: Amtolmetin guacil is a N-acyl-amino acid.
Brand nameArtromed
Clinical UseAmtolmetin guacil (AMG) is a non-steroidal anti-inflammatory drug developed by Sigma-Tau for the treatment of pain and inflammation. It acts similarly to tolmetin, and in preclinical trials displayed long-lasting anti-inflammatory and analgesic activity. Amtolmetin has a good gastrointestinal tolerability in humans and does not induce gastric ulcers in the rat . The good gastrointestinal tolerability and even a gastroprotective effect was related to an increase of endogenous NO via stimulation of inducible NO synthase in the gastric mucosa .
SynthesisThe condensation of 1-methyl- 5-(4-methylbenzoyl)pyrrole-2-acetic acid with glycine ethyl ester in the presence of carbonyldiimidazole and triethylamine in tetrahydrofuran gives the corresponding ethyl 2-acetate, which is hydrolyzed with NaOH in tetrahydrofuran – water yielding 2- - acetamido]acetic acid. Finally, this compound is esterified with 2-methoxyphenol (guaiacol) in hot tetrahydrofuran with carbonyldiimidazole as catalyst .
Synthesis_87344-06-7
Amtolmetin guacil Preparation Products And Raw materials
Tag:Amtolmetin guacil(87344-06-7) Related Product Information
Basic Violet 1 Methyl acrylate Fosfomycin tromethamine Tribenuron methyl Methylparaben Ketorolac tromethamine Pyrrole Polyvinylpyrrolidone Glycine Dexketoprofen trometamol TRISTEARIN Methanol N-Methyl-2-pyrrolidone Kresoxim-methyl Methyl salicylate N-Acetylglycine Methyl 2-Benzoylpyrrole