外消旋-莫地帕泛
| 中文名称 | 外消旋-莫地帕泛 |
|---|---|
| 中文同义词 | 外消旋-莫地帕泛;2-[4-(2-甲基-1H-咪唑并[4,5-C]吡啶-1-基)苯基]-4-(2-氯苯基)-5-[(2-吡啶基氨基)羰基]-6- 甲基-1,4-二氢吡啶-3-羧酸乙酯;化合物 T28081 |
| 英文名称 | modipafant |
| 英文同义词 | 2-[4-(2-Methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-4-(2-chlorophenyl)-5-[(2-pyridinylamino)carbonyl]-6-methyl-1,4-dihydropyridine-3-carboxylic acid ethyl ester;Modipefant;UK-74505;4-(2-Chlorophenyl)-1,4-dihydro-6-Methyl-2-[4-(2-Methyl-1H-iMidazo[4,5-c]pyridin-1-yl)phenyl]-5-[(2-pyridinylaMino)carbonyl]-3-pyridinecarboxylic Acid Ethyl Ester;rac-Modipafant;ethyl 4-(2-chlorophenyl)-6-methyl-2-(4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl)-5-(pyridin-2-ylcarbamoyl)-1,4-dihydropyridine-3-carboxylate(WXG02205);3-Pyridinecarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-2-[4-(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]-5-[(2-pyridinylamino)carbonyl]-, ethyl ester;Modipafant racemate |
| CAS号 | 122956-68-7 |
| 分子式 | C34H29ClN6O3 |
| 分子量 | 605.09 |
| EINECS号 | |
| 相关类别 | Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 122956-68-7.mol |
| 结构式 |  |
外消旋-莫地帕泛 性质
| 密度 | 1.34±0.1 g/cm3 (20 ºC 760 Torr) |
|---|---|
| 储存条件 | Store at -20°C |
| 酸度系数(pKa) | 12.14±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
(Rac)-Modipafant (UK-74505) 是一种口服的、选择性的、长效的不可逆血小板活化因子受体 (PAFR) 受体拮抗剂。(Rac)-Modipafant 预防严重登革热感染。
(Rac)-Modipafant (UK-74505) (10 mg/kg; p.o.; twice a day until day 10) prevents Severe Dengue Infection.
(Rac)-Modipafant exhibits highly selective, time-dependent inhibition of PAF-induced aggregation of rabbit washed platelets (IC
50
=26.3 and 1.12 nM after 0.25 and 60 min preincubation, respectively).
(Rac)-Modipafant (5-20 mg/kg; p.o.) dose-dependently inhibits the Zymosan -induced articular hyperalgesia.
| Animal Model: | 8- to 10-week-old BALB/c mice (DEN-2 strain infected) |
| Dosage: | 10 mg/kg |
| Administration: | P.o.; twice a day (started on days 0, 3, 5, or 7) until day 10 |
| Result: | Decreased by approximately 50% the lethality associated with DEN-2 infection. |
| Animal Model: | Male BALB/C (8- to 10- week-old) wild-type mice |
| Dosage: | 5, 10 and 20 mg/kg |
| Administration: | P.o. |
| Result: | Dose-dependently inhibited the Zymosan -induced articular hyperalgesia. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-108908 | (Rac)-Modipafant | 1 mg | 3400元 | |
| 2024/04/30 | HY-108908 | 外消旋-莫地帕泛 (Rac)-Modipafant | 122956-68-7 | 5 mg | 8500元 |