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Shanghai Chaolan Chemical Technology Center
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Product Name:2-[[3-[4-(Aminosulfonyl)phenyl]-3,4-dihydro-6-iodo-4-oxo-2-quinazolinyl]thio]-N-(2-ethylphenyl)acetamide
CAS:2439165-37-2
Purity:98% Package:50MG;100MG,1G,5G,100G
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| | 2-[[3-[4-(Aminosulfonyl)phenyl]-3,4-dihydro-6-iodo-4-oxo-2-quinazolinyl]thio]-N-(2-ethylphenyl)acetamide Basic information |
| | 2-[[3-[4-(Aminosulfonyl)phenyl]-3,4-dihydro-6-iodo-4-oxo-2-quinazolinyl]thio]-N-(2-ethylphenyl)acetamide Chemical Properties |
| Melting point | 314.3 °C | | density | 1.68±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | | pka | 10.11±0.10(Predicted) |
| | 2-[[3-[4-(Aminosulfonyl)phenyl]-3,4-dihydro-6-iodo-4-oxo-2-quinazolinyl]thio]-N-(2-ethylphenyl)acetamide Usage And Synthesis |
| Uses | Compound 9 is the most effective against tumor specific Ca ix/ca XII (ki=29.1 and 8.8 nm), so it is possible to evaluate its cytotoxicity and selectivity to HepG-2, HCT-116 and MCF-7 cancer cell lines in vitro, and its IC50 values to tumor cells are 1.78, 1.94 and 3.07, respectively μ M. It showed that it had obvious cytotoxicity. | | IC 50 | CA XII; CA Ⅱ; CA Ⅸ | | References | [1] Soliman AM,et al. Iodoquinazolinones bearing benzenesulfonamide as human carbonic anhydrase I, II, IX and XII inhibitors: Synthesis, biological evaluation and radiosensitizing activity. Eur J Med Chem. 2020 Aug 15;200:112449. DOI:10.1016/j.ejmech.2020.112449 |
| | 2-[[3-[4-(Aminosulfonyl)phenyl]-3,4-dihydro-6-iodo-4-oxo-2-quinazolinyl]thio]-N-(2-ethylphenyl)acetamide Preparation Products And Raw materials |
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