SARDOMOZIDE
| 中文名称 | SARDOMOZIDE |
|---|---|
| 中文同义词 | 2-(4-甲脒基-2,3-二氢-1H-茚-1-亚基)肼甲脒;化合物 T12833 |
| 英文名称 | 4-amidinoindan-1-one 2'-amidinohydrazone |
| 英文同义词 | (E)-2-(4-carbaMiMidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazinec;SardoMozide;CGP 48664;SAM 486A;2-(4-carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazinecarboximidamide;4-amidinoindan-1-one 2'-amidinohydrazone;(E)-2-(4-carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazinecarboximidamide;Hydrazinecarboximidamide, 2-[4-(aminoiminomethyl)-2,3-dihydro-1H-inden-1-ylidene]- |
| CAS号 | 149400-88-4 |
| 分子式 | C11H14N6 |
| 分子量 | 230.274 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 149400-88-4.mol |
| 结构式 |  |
SARDOMOZIDE 性质
| 沸点 | 438.8±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.54±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C(protect from light) |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 11.54±0.20(Predicted) |
Sardomozide 是一种 S-腺苷甲硫氨酸脱羧酶 (SAMDC) 抑制剂，其 IC50 值为 5 nM。
IC50: 5 nM (SAMDC)
Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC 50 of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells.