182073-77-4
中文名称 | 182073-77-4 |
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中文同义词 | 化合物 T17288;化合物 ZD8321 |
英文名称 | N''-[N-METHOXYCARBONYL-L-VALYL]-N-[(S)-3,3,3-TRIFLUOR-1-ISOPROPYL-2-OXOPROPYL]-L-PROLINAMIDE |
英文同义词 | N''-[N-METHOXYCARBONYL-L-VALYL]-N-[(S)-3,3,3-TRIFLUOR-1-ISOPROPYL-2-OXOPROPYL]-L-PROLINAMIDE;ZD8321;L-Prolinamide, N-(methoxycarbonyl)-L-valyl-N-[(1S)-3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl]-;ZD-8321,ZD8321 |
CAS号 | 182073-77-4 |
分子式 | C18H28F3N3O5 |
分子量 | 423.43 |
EINECS号 | |
相关类别 | |
Mol文件 | 182073-77-4.mol |
结构式 |
182073-77-4 性质
沸点 | 573.9±50.0 °C(Predicted) |
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密度 | 1.232±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
形态 | 固体 |
酸度系数(pKa) | 11.22±0.46(Predicted) |
颜色 | 浅黄至黄色 |
Ki: 13±1.7 nM (Neutrophil elastase)
TNFα-activated HUVEC is dose dependently inhibited by ZD8321.The adhesion between cancer cells with high elastase activity and TNFα-activated HUVEC is also inhibited by ZD8321. Expression of cell surface E-selectin by NE stimulation is suppressed in the presence of ZD8321. The concentration of soluble E-selectin in the medium increases after adhesive reaction between neutrophils and HUVEC. This increase is also dose dependently inhibited by ZD8321.