| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Anti-BTK
Purity:Ab1, Prestige Antibody
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| | ANTI-BTK Basic information |
| Product Name: | ANTI-BTK | | Synonyms: | ANTI-BTK;ANTI-BTK(C-20);ANTI-BTK, HUMAN;ANTI-BTK MOUSE MAB;ANTI-BRUTON'S TYROSINE KINASE, HUMAN;ANTI-BRUTON'S TYROSINE KINASE, HUMAN (MOUSE);ANTI-BRUTON'S TYROSINE KINASE MOUSE MAB;RABBIT ANTI-BTK | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-BTK Structure]() |
| | ANTI-BTK Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution |
| | ANTI-BTK Usage And Synthesis |
| Uses | Anti-BTK antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit . | | Biochem/physiol Actions | BTK (Bruton agammaglobulinemia tyrosine kinase) gene encodes a non-receptor tyrosine kinase that has a crucial role in B lymphocyte development, differentiation and signaling. It is essential for lipopolysaccharide (LPS)-induced as well as Toll-like receptors (TLR2 and TLR4)-induced tumor necrosis factor (TNF) production. Bright, a member of the ARID family of transcription factors, promotes immunoglobulin heavy-chain transcription via association with the transcription factor TFII-I and Btk. Btk interacts with and activates signaling by Toll-like receptors (TLR8 and TLR9) that are involved in the detection of pathogens and activation of host defense. Defects in this gene cause X-linked agammaglobulinaemia (XLA), a humoral immunodeficiency disease. |
| | ANTI-BTK Preparation Products And Raw materials |
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