RECILISIB 钠盐
中文名称 | RECILISIB 钠盐 |
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中文同义词 | RECILISIB 钠盐;磷酸氢二(2-乙氧基乙基);(E)-4-(2-((4-氯苄基)磺酰基)乙烯基)苯甲酸 |
英文名称 | 4-[(1E)-2-[[(4-CHLOROPHENYL)METHYL]SULFONYL]ETHENYL]-BENZOIC ACID |
英文同义词 | Recilisib sodium salt;4-[(1E)-2-[[(4-CHLOROPHENYL)METHYL]SULFONYL]ETHENYL]-BENZOIC ACID;Recilisib;Recilisib sodium;Recilisib sodium(ON01210);ON01210;4-Chlorobenzyl-4-carboxystyryl sulfone;Benzoic acid, 4-[(1E)-2-[[(4-chlorophenyl)methyl]sulfonyl]ethenyl]- |
CAS号 | 334969-03-8 |
分子式 | C16H13ClO4S |
分子量 | 336.79 |
EINECS号 | |
相关类别 | |
Mol文件 | 334969-03-8.mol |
结构式 | ![]() |
RECILISIB 钠盐 性质
沸点 | 607.8±55.0 °C(Predicted) |
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密度 | 1.423±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:35.71 mg/mL(106.03 mM) |
形态 | 固体 |
酸度系数(pKa) | 4.00±0.10(Predicted) |
颜色 | 白色至米白色 |
Akt
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PI3K
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Recilisib Sodium (up to 50 µM) shows a normal distribution of cells throughout the cell cycle, with a slight reduction in the number of cells in S-phase at 50 µM. Continuous exposure of Recilisib Sodium (100 µM) does not result in cell death. Recilisib Sodium does not inhibit the ability of human bone marrow to form colonies in methylcellulose at either timepoint. Recilisib Sodium treatment does not inhibit the colony forming potential of human bone marrow cells. Recilisib Sodium provides dose dependent protection of human bone marrow cells at all three doses of IR. Recilisib Sodium activates the phosphorylation of AKT and GSK3α/β in HFL cells. Recilisib Sodium increases PI3K activity in HFL-1 cells and murine bone marrow cells in response to radiation exposure. Recilisib Sodium treatment in combination with radiation alters the MAPK signaling pathway.
Recilisib Sodium (500 mg/kg) significantly increases the rate of recovery and differentiation of primitive bone marrow myeloid progenitor cells in mice. Recilisib Sodium in combination with radiation reduces CFU numbers in mice, but the Recilisib Sodium-treated mice consistently retain a capability to form differentiated colonies. Recilisib Sodium treated mice have a progenitor cell population that is never completely depleted by radiation exposure.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-101625 | Recilisib | 1 mg | 500元 | |
2024/04/30 | HY-101625 | RECILISIB 钠盐 Recilisib | 334969-03-8 | 5mg | 1100元 |