中文名称 | 4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene |
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中文同义词 | |
英文名称 | 4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene |
英文同义词 | [2-[4-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]phenyl]-6-hydroxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]Methanone;6-Hydroxy-4'-tert-butyldiMethylsylyl Raloxifene;4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene;4a€-tert-Butyldimethylsilyl-6-hydroxy Raloxifene;Methanone, [2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-6-hydroxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-;Sulfamic Acid Impurity 6 |
CAS号 | 174264-46-1 |
分子式 | C34H41NO4SSi |
分子量 | 587.84414 |
EINECS号 | |
相关类别 | Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceuticals, Intermediates & Fine Chemicals |
Mol文件 | 174264-46-1.mol |
结构式 | ![]() |
4’-tert-Butyldimethylsilyl-6-hydroxy Raloxifene 性质
储存条件 | Refrigerator |
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溶解度 | 可溶于丙酮、氯仿、二氯甲烷、乙醇、甲醇 |
形态 | 固体 |
颜色 | 粘黄色 |
CAS 数据库 | 174264-46-1 |
The preparation of the Raloxifene 6-glucuronide includes: (a) reaction of Raloxifene with tertbutyldimethylsilyl chloride to give a chromatographically separable mixture of Compound 3 and 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene (Compound 4); (b) Lewis acid mediated coupling of phenol 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene with methyl1,2,3,4-tetra-O-acetyl-D-glucopyranuronate to provide a single product (Compound 6) with the desired flstereochemistry at the anomeric center; (c) heating Compound 6 with lithium hydroxide in dioxane to 60°C, followed by deprotection with tetrabutylammonium fluoride to give Raloxifene 6-glucuronide.