LY 341495

LY 341495 Suppliers list
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:ly 341495
CAS:201943-63-7
Purity:0.99 Package:1kg
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
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Products Intro: Product Name:LY341495
CAS:201943-63-7
Purity:98.00% Package:1 mL * 10mM (in DMSO);10 mg;100 mg;2 mg;25 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Hefei Hirisun Pharmatech Co., Ltd
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Products Intro: Product Name:(2S)-2-AMINO-2-[(1S,2S)-2-CARBOXYCYCLOPROP-1-YL]-3-(XANTH-9-YL) PROPANOIC ACID
CAS:201943-63-7
Purity:0.95 Package:1G;5G;25G;Bulk for inquiry Remarks:HR130728
Company Name: InvivoChem
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Products Intro: Product Name:LY-341495
CAS:201943-63-7
Purity:98% Package:5mg Remarks:V4867
Company Name: Aladdin Scientific
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Products Intro: Product Name:LY341495
CAS:201943-63-7
Purity:>=98% Package:$49.9/1mg;$107.9/5mg;$259.9/10mg;$519.9/25mg;$836.9/50mg;$1339.9/100mg;Bulk pack Remarks:98%
LY 341495 Basic information
Product Name:LY 341495
Synonyms:LY 341495;(2S)-2-AMINO-2-[(1S,2S)-2-CARBOXYCYCLOPROP-1-YL]-3-(XANTH-9-YL) PROPANOIC ACID;(alphaS)-alpha-Amino-alpha-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid LY 341495;(alphaS)-alpha-Amino-alpha-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid;CS-416;(1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]cyclopropane-1-carboxylic acid;LY 341495;LY-341495;9H-Xanthene-9-propanoic acid, α-amino-α-[(1S,2S)-2-carboxycyclopropyl]-, (αS)-
CAS:201943-63-7
MF:C20H19NO5
MW:353.37
EINECS:
Product Categories:Glutamate
Mol File:201943-63-7.mol
LY 341495 Structure
LY 341495 Chemical Properties
Boiling point 580.8±40.0 °C(Predicted)
density 1.432
storage temp. Store at RT
solubility Limited solubility, soluble in DMSO
form crystalline solid
pka2.02±0.10(Predicted)
color White to off-white
Safety Information
MSDS Information
LY 341495 Usage And Synthesis
UsesLY-341495 is a potent and selective group II metabotropic glutamate receptor (mGluR) antagonist.
UsesLY 341495 is a potent and selective antagonist of the group II metabotropic glutamate receptors (mGluR), mGluR2 and mGluR3 (IC50s = 21 and 14 nM, respectively, for human isoforms). It less effectively blocks mGluR8 and mGluR7 (IC50s = 173 and 990 nM, respectively) and weakly antagonizes mGluR1, mGluR5, and mGluR4 (IC50s = 6.8, 8.2, and 22 μM, respectively). In rat forebrain tissue, LY341495 may bind mGluR3 more avidly than mGluR2. LY341495 can be effectively used in isolated cells, tissues, and in vivo. In mice, it penetrates the blood-brain barrier and has been used to study the roles of mGlu2/3 receptors in the brain.[Cayman Chemical]
DefinitionChEBI: (1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]-1-cyclopropanecarboxylic acid is a member of xanthenes.
Biological ActivityHighly potent and selective group II metabotropic glutamate receptor antagonist (K i /IC 50 values are 2.3, 1.3, 173, 990, 6800, 8200 and 22000 nM for human mGlu 2 , mGlu 3 , mGlu 8 , mGlu 7a , mGlu 1a , mGlu 5a and mGlu 4a receptors respectively). Readily brain penetrant and active in vivo . Also available as part of the Group II mGlu Receptor Tocriset™ , Group III mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .
storageRoom temperature
references[1] kingston a e, ornstein p l, wright r a, et al. ly341495 is a nanomolar potent and selective antagonist of group ii metabotropic glutamate receptors. neuropharmacology, 1998, 37(1): 1-12.
[2] fitzjohn s m, bortolotto z a, palmer m j, et al. the potent mglu receptor antagonist ly341495 identifies roles for both cloned and novel mglu receptors in hippocampal synaptic plasticity. neuropharmacology, 1998, 37(12): 1445-1458.
[3] pitsikas n, kaffe e, markou a. the metabotropic glutamate 2/3 receptor antagonist ly341495 differentially affects recognition memory in rats. behavioural brain research, 2012, 230(2): 374-379.
LY 341495 Preparation Products And Raw materials
Tag:LY 341495(201943-63-7) Related Product Information
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