1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride
| 中文名称 | 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride |
|---|---|
| 中文同义词 | 化合物 T23110 |
| 英文名称 | 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride |
| 英文同义词 | 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride;1-[6-Chloro-5-trifluoromethyl)-2-pyridinyl]-piperazinehydrochloride;Org 12962 hydrochloride;Org12962HCl;Org 12692;Piperazine, 1-[6-chloro-5-(trifluoromethyl)-2-pyridinyl]-, hydrochloride (1:1) |
| CAS号 | 210821-63-9 |
| 分子式 | C10H11ClF3N3.ClH |
| 分子量 | 302.126 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 210821-63-9.mol |
| 结构式 |  |
1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride 性质
| 储存条件 | Sealed in dry,Room Temperature |
|---|---|
| 溶解度 | 在水中溶解度为 50 mM，在 DMSO 中溶解度为 100 mM |
| 形态 | 淡黄色固体。 |
Org 12962 hydrochloride 是一种有效的、选择性的 5-HT2C 受体激动剂，对 5-HT2C，5-HT2A，5-HT2B 的 pEC50 分别为 7.01、6.38 和 6.28。Org 12962 hydrochloride 在焦虑大鼠的模型中显示出缓解作用。
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5-HT 2C Receptor 7.01 (pEC 50 ) |
5-HT 2A Receptor 6.38 (pEC 50 ) |
5-HT 2B Receptor 6.28 (pEC 50 ) |
Org 12962 (intraperitoneal injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg) displays antiaversive effects in a rat model of panic-like anxiety, it increases the postinjection frequency thresholds for self-interruption (F 3.71 =11.40). The dose of 0.3 mg/kg ip is not significantly active, that the dose of 1 mg/kg is marginally active and that 3.2 mg/kg ip induced highly significant antiaversive effects.
| Animal Model: | Male Wistar rats |
| Dosage: | 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg |
| Administration: | Intraperitoneal injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg |
| Result: | Had a dose-related antipanic-like effect in SD-rat. |