|
| (S)-N-Fmoc-2-(2'-propylenyl)alanine Basic information |
Product Name: | (S)-N-Fmoc-2-(2'-propylenyl)alanine | Synonyms: | (S)-N-Fmoc-2-(2'-propylenyl)alanine;(2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-4-pentenoic acid;(S)-N-Fmoc-alpha-allylalanine;(S)-N-(9-Fluorenylmethylcarbamate)-2-(2'-propylenyl)alanine;Fmoc-alpha-methyl-L-allylglycine;(S)-N-FMOC-Α-ALLYLALANINE;FMoc-α-Me-Gly(Allyl)-OH;(S)-N-Fmoc-α-2-n-propenylalanine | CAS: | 288617-71-0 | MF: | C21H21NO4 | MW: | 351.4 | EINECS: | | Product Categories: | α-Methyl Amino Acids | Mol File: | 288617-71-0.mol | |
| (S)-N-Fmoc-2-(2'-propylenyl)alanine Chemical Properties |
Boiling point | 564.3±45.0 °C(Predicted) | density | 1.224 | storage temp. | Inert atmosphere,Store in freezer, under -20°C | pka | 3.81±0.11(Predicted) | form | liquid | color | pale yellow | InChIKey | FNCSRFHDUZYOCR-NRFANRHFSA-N |
Hazard Codes | N | Risk Statements | 50 | Safety Statements | 61 | RIDADR | UN 3077 9 / PGIII | WGK Germany | 3 | TSCA | No |
| (S)-N-Fmoc-2-(2'-propylenyl)alanine Usage And Synthesis |
Uses | Olefinic alpha-methyl amino acid for peptide stapling. Upon incorporation of this amino acid into a peptide, along with another of the same or derivative with a different length of the olefinic side chain, the two can be ′stapled′ via a ring closing metathesis reaction with Grubb′s catalyst (product # 579726). The resulting stapled peptide macrocycle has been shown to stabilize the alpha-helical structure of peptides, which can lead to favorable biological characteristics such as increased proteolytic stability and cellular uptake. |
| (S)-N-Fmoc-2-(2'-propylenyl)alanine Preparation Products And Raw materials |
|