|
|
| | Methyl 2-(Boc-amino)isonicotinate Basic information |
| Product Name: | Methyl 2-(Boc-amino)isonicotinate | | Synonyms: | 2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-pyridinecarboxylic acidmethylester;Methyl 2-(Boc-amino)isonicotinate;4-Pyridinecarboxylic acid, 2-[[(1,1-diMethylethoxy)carbonyl]aMino]-, Methyl ester;Methyl 2-((tert-butoxycarbonyl)aMino)isonicotinate;2-Boc-amino-isonicotinic acid methyl ester;2-tert-Butoxycarbonylamino-isonicotinic acid methyl ester;Methyl 2-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-4-carboxylate;methyl 2-(tert-butoxycarbonylamino)pyridine-4-carboxylate | | CAS: | 639091-75-1 | | MF: | C12H16N2O4 | | MW: | 252.27 | | EINECS: | | | Product Categories: | | | Mol File: | 639091-75-1.mol |  |
| | Methyl 2-(Boc-amino)isonicotinate Chemical Properties |
| Melting point | 75.1～75.2℃ | | Boiling point | 325.5±27.0 °C(Predicted) | | density | 1.203±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 12.12±0.70(Predicted) |
| | Methyl 2-(Boc-amino)isonicotinate Usage And Synthesis |
| Synthesis | A 500 mL round bottomed flask was charged with methyl 2-aminoisonicotinate (5.0 g, 32.9 mmol) and suspended in t-BuOH (200 mL). To this stirring solution was added di-tert-butyl dicarbonate (7.53 g, 34.5 mmol). The flask was vented and placed in an oil bath preheated to 50°C. The reaction mixture was let stir overnight. After 22 hours LCMS showed near complete conversion of starting material. The mixture was cooled to room temperature and filtered. The material was taken on without any further purification. Yield 5.93 g of white solid, Methyl 2-(Boc-amino)isonicotinate. 1H NMR (400 MHz, DMSO-d6) δ ppm 10.14 (1H, s), 8.43 (1H, dd, J=5.02, 0.75 Hz), 8.33 (1H, s), 7.45 (1H, dd, J=5.02, 1.51 Hz), 3.89 (3H, s), 1.48 (9H, s).
 |
| | Methyl 2-(Boc-amino)isonicotinate Preparation Products And Raw materials |
|