216691-95-1
中文名称 | 216691-95-1 |
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中文同义词 | 化合物 T14846 |
英文名称 | 7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthylmethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one |
英文同义词 | 7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthylmethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one;Bz-423;2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-Methyl-3-(2-naphthalenylMethyl)-;7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one;BZ48;Bz-423 >=98% (HPLC);Bz 423 (BZ48) |
CAS号 | 216691-95-1 |
分子式 | C27H21ClN2O2 |
分子量 | 440.92 |
EINECS号 | |
相关类别 | |
Mol文件 | 216691-95-1.mol |
结构式 | ![]() |
216691-95-1 性质
沸点 | 697.2±55.0 °C(Predicted) |
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密度 | 1.28±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:≥ 125 mg/mL(283.50 mM) |
酸度系数(pKa) | 9.05±0.30(Predicted) |
Bax
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Bak
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Bz-423 induces a larger superoxide response in Ramos cells, and causes rapid death of Ramos B cells. Bz-423 activates Bax and Bak, but does not activate ASK1/JNK in Ramos cells. In Ramos cells Bz-423-induced superoxide leads to Bax and Bak activation via changes in Mcl-1 expression and functional activation of BH3-only proteins. Bz-423 rapidly increases superoxide levels in MEFs within 1 h and the magnitude of the increase is concentration-dependent. Bz-423-induced apoptosis dependents upon superoxide.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-13108 | 216691-95-1 Bz 423 | 216691-95-1 | 5mg | 950元 |
2024/04/30 | HY-13108 | 216691-95-1 Bz 423 | 216691-95-1 | 10mM * 1mLin DMSO | 1050元 |