| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
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Product Name:()-trans-C75
CAS:1234694-22-4
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
MedBioPharmaceutical Technology Inc
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021-69568360 18916172912 |
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order@med-bio.cn |
| Products Intro: |
Product Name:()-trans-C75
CAS:1234694-22-4
Purity:98% Package:1mg; 10mg; 5mg Remarks:Medbio
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627 |
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customer_service@efebio.com |
| Products Intro: |
Product Name:()-trans-C75
CAS:1234694-22-4
Purity:97% Package:1mg;5mg
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| Company Name: |
ApexBio Technology
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+ 1-832-696-8203 |
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sales@apexbt.com |
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Product Name:()-trans-C75
CAS:1234694-22-4
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| Company Name: |
Cayman Chemical Company
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(800) 364-9897 |
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cayman@caymanchem.com |
| Products Intro: |
Product Name:()-trans-C75
CAS:1234694-22-4
Package:>=98% Remarks:9000784
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| | ()-trans-C75 Basic information |
| Product Name: | ()-trans-C75 | | Synonyms: | ()-trans-C75;3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-, (2S,3R)- | | CAS: | 1234694-22-4 | | MF: | C14H22O4 | | MW: | 254.32 | | EINECS: | | | Product Categories: | | | Mol File: | 1234694-22-4.mol |  |
| | ()-trans-C75 Chemical Properties |
| Melting point | 88-90 °C | | Boiling point | 432.1±45.0 °C(Predicted) | | density | 1.08±0.1 g/cm3(Predicted) | | solubility | DMF: 30 mg/ml; DMSO: 10 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 0.5 mg/ml | | form | A crystalline solid | | pka | 3.08±0.40(Predicted) |
| | ()-trans-C75 Usage And Synthesis |
| Description | C75 is stable fatty acid synthase (FASN) inhibitor that when administered in racemic form leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.1 C75 is also cytotoxic to many human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FASN pathway.2 (?)-trans-C75 is an enantiomer of C75.3 Its biologicial activity has not been reported. | | Definition | ChEBI: (2S,3R)-C75 is a 4-methylidene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid that has 2S,3R-configuration. It is an enantiomer of a (2R,3S)-C75. | | References | 1. Loftus, T.M., Jaworsky, D.E., Frehywot, G.L., et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors Science 288,2379-2381(2000).
2. Pizer, E.S., Thupari, J., Han, W.F., et al. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts Cancer Res. 60,213-218(2000).
3. Chakrabarty, K., Forzato, C., Nitti, P., et al. The first kinetic enzymatic resolution of methyl ester of C75 Lett. Org. Chem. 7,245-248(2010). |
| | ()-trans-C75 Preparation Products And Raw materials |
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