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Product Name:Acetyl podocarpic acid anhydride
CAS:344327-48-6
Purity:98% Package:1G;10G;100G Remarks:Acetyl podocarpic acid anhydride (APD) is potent, semi-synthetic LXR agonist derived from extracts of the mayapple.
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Product Name:Acetyl Podocarpic Acid Anhydride
CAS:344327-48-6
Purity:98% Package:50mg; 5mg; 10mg Remarks:Medbio
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Product Name:Acetyl Podocarpic Acid Anhydride
CAS:344327-48-6
Purity:98% Package:1mg;5mg;10mg
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Product Name:Acetyl podocarpic acid anhydride
CAS:344327-48-6
Purity:5mg;10mg;50mg;100mg;250mg;500mg;1g Package:5mg;10mg;50mg;100mg;250mg;500mg;1g
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Product Name:Acetyl Podocarpic Acid Anhydride
CAS:344327-48-6
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| | Acetyl Podocarpic Acid Anhydride Basic information |
| Product Name: | Acetyl Podocarpic Acid Anhydride | | Synonyms: | Acetyl Podocarpic Acid Anhydride;OUJQRQRBNRGQTC-SPGSYPTKSA-N;1-Phenanthrenecarboxylic acid, 6-(acetyloxy)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-, anhydride with 6-(acetyloxy)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-1-phenanthrenecarboxylic acid, (1S,4aS,10aR)-;Acetylpodocarpic dimer | | CAS: | 344327-48-6 | | MF: | C38H46O7 | | MW: | 614.77 | | EINECS: | | | Product Categories: | | | Mol File: | 344327-48-6.mol |  |
| | Acetyl Podocarpic Acid Anhydride Chemical Properties |
| Boiling point | 695.5±55.0 °C(Predicted) | | density | 1.170±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 1 mg/ml | | form | A crystalline solid | | color | White to off-white |
| | Acetyl Podocarpic Acid Anhydride Usage And Synthesis |
| Description | The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols.1 Acetyl podocarpic acid anhydride (APD) is a potent, semisynthetic LXR agonist derived from extracts of the mayapple. APD acting through LXR in concert with the retinoid X receptor (RXR), its heterodimerization partner, induces the expression of the ABCA1 reverse cholesterol transporter.2 This acts to increase the efflux of cholesterol from enterocytes and thus inhibits the overall absorption of cholesterol (ED50 value of 1 nM).3 In transient transactivation assays, APD was found to be approximately 1,000 times more potent and have 8-10-fold greater maximal stimulation of LXR than 22(R)-hydroxy cholesterol.3,4 APD can be used as a positive control for the testing of LXR agonists, which have potential as therapeutic agents for the treatment of atherosclerosis. | | Definition | ChEBI: Acetyl Podocarpic Acid Anhydride is a diterpenoid. | | References | 1. Repa, J.J., Turley, S.D., Lobaccaro, J.M.A., et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers Science 289(5484),1524-1529(2000).
2. Costet, P., Luo, Y., Wang, N., et al. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor J. Biol. Chem. 275(36),28240-28245(2000).
3. Sparrow, C.P., Baffic, J., Lam, M.H., et al. A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux J. Biol. Chem. 277(12),10021-10027(2002).
4. Singh, S.B., Ondeyka, J.G., Liu, W., et al. Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters Bioorg. Med. Chem. Lett. 15(11),2824-2828(2005). |
| | Acetyl Podocarpic Acid Anhydride Preparation Products And Raw materials |
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