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Product Name:F-Amidine trifluoroacetate salt
CAS:877617-46-4
Purity:95% Package:1G;10G;100G
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Product Name:F-Amidine (trifluoroacetate salt)
CAS:877617-46-4
Purity:>98% Package:1mg;10mg;50mg;100mg;
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Product Name:F-Amidine trifluoroacetate salt
CAS:877617-46-4
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Product Name:F-Amidine (trifluoroacetate salt)
CAS:877617-46-4
Purity:98% Package:100ug (solution); 250ug (solution); 500ug (solution); 1mg (solution) Remarks:Medbio
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Product Name:F-Amidine (trifluoroacetate salt)
CAS:877617-46-4
Purity:95% Package:100μg;250μg;500μg
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| | F-Amidine (trifluoroacetate salt) Basic information |
| | F-Amidine (trifluoroacetate salt) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml |
| | F-Amidine (trifluoroacetate salt) Usage And Synthesis |
| Uses | Peptidyl arginine deiminase 4 (PAD4, Protein arginine deiminase 4) catalyzes the post-translational modification of arginine residues on histones to form citrulline, which plays a large role in regulating gene expression. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. F-amidine inhibits PAD4 activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for its catalytic activity. F-amidine also inhibits PAD1 and PAD3 with IC50 values of 29.5 and 350 μM, respectively. F-amidine is cytotoxic to HL-60, MCF-7, and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).[Cayman Chemical] |
| | F-Amidine (trifluoroacetate salt) Preparation Products And Raw materials |
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