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JWH 018 2'-naphthyl-N-(2,2-dimethylpropyl) isomer

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CAS:1869954-38-0
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Products Intro: Product Name:JWH 018 2'-naphthyl-N-(2,2-dimethylpropyl) isomer
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Products Intro: Product Name:JWH 018 2'-naphthyl-N-(2,2-dimethylpropyl) isomer
CAS:1869954-38-0
JWH 018 2'-naphthyl-N-(2,2-dimethylpropyl) isomer Basic information
Product Name:JWH 018 2'-naphthyl-N-(2,2-dimethylpropyl) isomer
Synonyms:JWH 018 2'-naphthyl-N-(2,2-dimethylpropyl) isomer;[1-(2,2-dimethylpropyl)-1H-indol-3-yl]-2-naphthalenyl-methanone;-naphthyl-N-(2,2-dimethylpropyl) isomer;Methanone, [1-(2,2-dimethylpropyl)-1H-indol-3-yl]-2-naphthalenyl-
CAS:1869954-38-0
MF:C24H23NO
MW:341.45
EINECS:
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Mol File:1869954-38-0.mol
JWH 018 2'-naphthyl-N-(2,2-dimethylpropyl) isomer Structure
JWH 018 2'-naphthyl-N-(2,2-dimethylpropyl) isomer Chemical Properties
Boiling point 523.4±23.0 °C(Predicted)
density 1.08±0.1 g/cm3(Predicted)
solubility DMF: 20 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml
form A crystalline solid
Safety Information
MSDS Information
JWH 018 2'-naphthyl-N-(2,2-dimethylpropyl) isomer Usage And Synthesis
DescriptionJWH 018 (1-pentyl-3-(1-naphthoyl)indole) is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 9.0 and 2.94 nM, respectively).1 This cannabimimetic compound has frequently been found in herbal blends. 2,3,4 JWH 018 2’-naphthyl-N-(2,2-dimethylpropyl) isomer differs structurally from JWH 018 by having the naphthyl group attached at the 2’ position and 2,2-dimethylpropyl in place of the pentyl chain. The biological activities of this compound have not been characterized.
References1. Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding Drug Alcohol Depend. 60(2),133-140(2000).
2. Auw?rter, V., Dresen, S., Weinmann, W., et al. “Spice” and other herbal blends: Harmless incense or cannabinoid designer drugs? J. Mass Spectrom. 44(5),832-837(2009).
3. Lindigkeit, R., Boehme, A., Eiserloh, I., et al. Spice: A never ending story? Forensic Sci. Int. 191(1-3),58-63(2009).
4. Uchiyama, N., Kikura-Hanajiri, R., Kawahara, N., et al. Identification of a cannabimimetic indole as a designer drug in a herbal product Forensic Toxicol. 27,61-66(2009).
JWH 018 2'-naphthyl-N-(2,2-dimethylpropyl) isomer Preparation Products And Raw materials
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